Differential age effects on cerebral blood flow and BOLD response to encoding: Associations with cognition and stroke risk
Differential age effects on cerebral blood flow and BOLD response to encoding: Associations with cognition and stroke risk
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DOI：
10.1016/j.neurobiolaging.2007.11.012
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发表时间：
2009-08-01
影响因子：
4.2
通讯作者：
Bondi, Mark W.
中科院分区：
文献类型：
--
作者：
Bangen, Katherine J.;Restom, Khaled;Bondi, Mark W.
由于年龄或疾病引起的脑血管系统变化可显著改变血氧水平依赖性（BOLD）信号并使其解释复杂化。同时获取动脉自旋标记（ASL）和BOLD数据是一种有用的技术，可以更全面地表征脑功能认知反应的神经血管基础。我们对情景记忆编码进行了功能磁共振成像（FMRI）研究，以探讨年龄是否与脑血流量（CBF）和内侧颞叶（MTL）的BOLD反应有关。结果显示，与年轻人相比，老年人静息状态CBF显著减少。相反，与年轻人相比，老年人在图像编码过程中表现出明显增加的CBF，但在MTL中没有BOLD反应。CBF反应和认知之间的相关性得到证实，而与BOLD的关联未被观察到。卒中风险与CBF和BOLD反应均相关。结果表明，衰老对CBF和BOLD编码反应的影响是可分离的，脑血管的改变有助于发现年龄相关的差异。Elsevier Inc.出版。
Changes in the cerebrovascular system due to age or disease can significantly alter the blood-oxygenation-level-dependent (BOLD) signal and complicate its interpretation. The simultaneous acquisition of arterial spin labeling (ASL) and BOLD data represents a useful technique to more fully characterize the neurovascular underpinnings of functional brain response to cognition. We conducted a functional magnetic resonance imaging (FMRI) study of episodic memory encoding to investigate whether age is related to cerebral blood flow (CBF) and BOLD response in the medial temporal lobe (MTL). Results demonstrated a significant reduction in resting-state CBF in older compared to young adults. Conversely, older adults showed significantly increased CBF but not BOLD response in the MTL during picture encoding relative to young adults. Correlations between CBF response and cognition were demonstrated whereas associations with BOLD were not observed. Stroke risk was associated with both CBF and BOLD response. Results suggest that aging effects on CBF and BOLD responses to encoding are dissociable and that cerebrovascular alterations contribute to findings of age-related differences. Published by Elsevier Inc.