Interleukin-17A-Producing T Lymphocytes in Chronic Active Epstein-Barr Virus Infection.
Interleukin-17A-Producing T Lymphocytes in Chronic Active Epstein-Barr Virus Infection.
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慢性活动性 Epstein-Barr 病毒感染中产生白细胞介素 17A 的 T 淋巴细胞。
DOI：
10.1111/1348-0421.12010
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发表时间：
2013
影响因子：
2.6
通讯作者：
Ohta R
中科院分区：
文献类型：
--
作者：
Isobe Y;Hamano Y;Ito Y;Kimura H;Tsukada N;Sugimoto K;Komatsu N.;Ohta R
据报道，T辅助细胞(Th)17是产生白细胞介素17A(IL-17A)的效应性T细胞，在自身免疫性疾病的发生和抗微生物宿主防御的免疫反应中发挥重要作用。研究慢性活动性EB病毒感染(CAEBV)时IL-17A的产生，探讨其在本病发病机制中的作用。CAEBV患者外周血中检测到的IL-17A产生细胞明显多于健康对照组，但血清IL-17A产生的差异尚未得到证实。在产生IL-17A的细胞中，91.8%为分化簇(CD)4阳性的Th17细胞。CAEBV患者外周血中产生IL-17A的细胞明显多于对照组(1.97 ± 0.69%vs.1.09 ± 0.53%，P= 0.0073)。这些数据表明，产生IL-17A的细胞可能影响CAEBV的病理生理。
T helper (Th) 17 cells are reportedly effector T cells that produce interleukin (IL)‐17A and play a significant role in the development of autoimmune diseases and immune responses for antimicrobial host defense. Production of IL‐17A in chronic active Epstein–Barr virus infection (CAEBV) was studied to investigate its contribution to pathogenesis of this disease. Significantly more IL‐17A‐producing cells were detected in the peripheral blood of CAEBV patients than in that of healthy controls, although a significant difference in serum IL‐17A production was not confirmed. Of the IL‐17A‐producing cells, 91.8% were cluster of differentiation (CD)4‐positive Th17 cells. Moreover, there were significantly more IL‐17A‐producing cells among CD4+cells in peripheral blood of CAEBV patients than in that of controls (1.97 ± 0.69% vs. 1.09 ± 0.53%,P= 0.0073). These data suggest that IL‐17A‐producing cells may influence the pathophysiology of CAEBV.