Scoring of radiographic progression in randomised clinical trials in ankylosing spondylitis:: a preference for paired reading order
Scoring of radiographic progression in randomised clinical trials in ankylosing spondylitis:: a preference for paired reading order
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DOI：
10.1136/ard.2004.022038
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发表时间：
2004-12-01
影响因子：
27.4
通讯作者：
van der Heijde, D
中科院分区：
文献类型：
--
作者：
Wanders, A;Landewé, R;van der Heijde, D
目的：描述强直性脊柱炎的阅读顺序(按时间顺序v配对)对放射学评分结果的影响。为了调查这种方法是否对变化足够敏感，因为在临床试验中需要配对阅读来确定药物疗效。方法：由一名观察者对166名患者(基线、1年和2年)的X光片进行评分，使用改良的Stoke强直性脊柱炎脊柱评分。结果：1年(平均(SD)1.3(2.6)比0.5(2.4)个单位)和2年(2.1(3.9)比1.0(2.9)个单位)时间顺序阅读比配对阅读有更多的进步；方法间差异有统计学意义(P
Objectives: To describe the influence of the reading order (chronological v paired) on radiographic scoring results in ankylosing spondylitis. To investigate whether this method is sufficiently sensitive to change because paired reading is requested for establishing drug efficacy in clinical trials.Methods: Films obtained from 166 patients (at baseline, 1 year, and 2 years) were scored by one observer, using the modified Stoke Ankylosing Spondylitis Spinal Score. Films were first scored chronologically, and were scored paired 6 months later.Results: Chronological reading showed significantly more progression than paired reading both at 1 year (mean (SD) progression 1.3 (2.6) v 0.5 (2.4) units) and at 2 years (2.1 (3.9) v 1.0 (2.9) units); between-method difference: p