CHANGES IN MEMBRANE CHARACTERISTICS OF HEART MUSCLE DURING INHIBITION
CHANGES IN MEMBRANE CHARACTERISTICS OF HEART MUSCLE DURING INHIBITION
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DOI：
10.1085/jgp.40.1.135
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发表时间：
1956-01-01
影响因子：
3.8
通讯作者：
EDWARDS, C
中科院分区：
文献类型：
--
作者：
TRAUTWEIN, W;KUFFLER, SW;EDWARDS, C
通过测量阈下电势的时间过程和空间分布的变化，研究了青蛙耳廓的分离肌束的膜特性。如果应用乙酰胆碱的浓度导致心跳减慢或停止，则会产生以下变化：（a）膜的长度常数（A）减小，（b）时间常数（r）缩短。这种影响是可逆的，并随着乙酰胆碱浓度的增加而增加。乙酰胆碱引起的膜变化随着时间的推移而减少。结论是，在乙酰胆碱抑制期间以及迷走神经抑制期间，膜的电导增加，并且静息膜电位的明显变化不需要伴随抑制。
Membrane characteristics were studied in isolated muscle strands from auricles of frogs by measuring the changes in the time course and spatial spread of subthreshold electrotonic potentials. If acetylcholine is applied in concentrations which cause slowing or stoppage of the heart beat, the following changes are produced: (a) the length constant (A) of the membrane is reduced, (b) the time constant (r) is shortened. The effects are reversible and increase with acetycholine concentration. The membrane changes caused by acetylcholine decrease with time. It is concluded that during acetylcholine inhibition, as well as during vagal inhibition, the conductance of the membrane is increased, and that appreciable changes in the resting membrane potential need not accompany inhibition.