DIET AND BREAST-CANCER - A CASE-CONTROL STUDY IN GREECE
DIET AND BREAST-CANCER - A CASE-CONTROL STUDY IN GREECE
复制标题
DOI：
10.1002/ijc.2910380606
复制
发表时间：
1986-12-15
影响因子：
6.4
通讯作者：
MACMAHON, B
中科院分区：
文献类型：
--
作者：
KATSOUYANNI, K;TRICHOPOULOS, D;MACMAHON, B
在希腊雅典进行了一项关于饮食在乳腺癌病因学中作用的病例对照研究。有理由相信，希腊人口的饮食特点是更大的异质性比大多数国家，在这种研究已经进行。该病例系列包括120例连续的组织学确诊的乳腺癌患者，在12个月内入住两家教学医院。对照组为同一时期因创伤和骨科疾病入住教学医院的120例患者。通过访谈获得了关于120种食物和饮料的消费频率的饮食史。病例报告的蔬菜消费频率明显降低，在该组中，特别是黄瓜、生菜和生胡萝卜。在调整潜在的外部混杂变量和食物类别之间的混杂后，蔬菜消费者中最高五分之一的人相对于最低五分之一的人的比值比为0.09，95%置信限为0.03-0.30。也就是说，最低五分之一的蔬菜消费者患乳腺癌的风险是最高五分之一的人的10倍。对于基于仅食用3种指定沙拉的评分，极端四分位数的比值比为0.12（0.05-0.32）。在调整混杂变量后，与脂肪和油，酒精或咖啡的消费没有关联，与任何其他主要食物类别（包括酒精和咖啡）也没有显著关联。
A case-control study of the role of diet in the etiology or breast cancer was conducted in Athens, Greece. There are reasons to believe that the diet of the Greek population is characterized by greater heterogeneity than that in most countries where such studies have been undertaken. The case series consisted of 120 consecutive patients with histologically confirmed breast cancer admitted to either of two teaching hospitals over a 12-month period. The controls were 120 patients admitted to a teaching hospital for trauma and orthopedic conditions during the same period. Dietary histories concerning the frequency of consumption of 120 foods and drinks were obtained by interview. Cases reported significantly less frequent consumption of vegetables as a group and, within that group, specificially of cucumber, lettuce and raw carrot. After adjustment for potential external confounding variables and for confounding between food catergories, the odds ratio for persons in the highest quintile of vegetable consumers, relative to those in the lowest quintile, was 0.09 with 95% confidence limits 0.03-0.30. That is to say, the lowest quintile of vegetable consumers had about 10 times the breast cancer risk of the highest quintile. For a score based on consumption of only the 3 specified salad items the odds ratio over the extreme quartiles was 0.12 (0.05-0.32). There was no association with consumption of fats and oils, alcohol or coffee, and no significant association with any other major food category (including alcohol and coffee) after adjustment for confounding variables.