Passive and wireless, implantable glucose sensing with phenylboronic acid hydrogel-interlayer RF resonators
Passive and wireless, implantable glucose sensing with phenylboronic acid hydrogel-interlayer RF resonators
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DOI：
10.1016/j.bios.2020.112004
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发表时间：
2020-03-01
影响因子：
12.6
通讯作者：
Tseng, Peter
中科院分区：
文献类型：
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作者：
Dautta, Manik;Alshetaiwi, Muhannad;Tseng, Peter
基于苯基硼酸的水凝胶夹层射频（RF）谐振器被证明是一种用于葡萄糖监测的高响应、无源和无线传感器。构建体由葡萄糖响应性水凝胶介导的未锚定的电容偶联的开口环组成。苯基硼酸水凝胶表现出体积和介电响应于环境中的葡萄糖浓度的变化，这些有效地转换为层间RF传感器的谐振响应的大位移。这些微型、可拉伸和可扩展的传感器（5 mm x 5 mm x 250 mu m）在传感节点不需要微电子或电源，并且可以通过近场耦合远程读取。传感器表现出高灵敏度（类似于共振频率的10%偏移-对应于50 MHz-每150 mg/dL葡萄糖），具有10 mg/dL的检测限，以及对碳水化合物浓度突变的阶跃响应时间约为1 h。值得注意的是，这些传感器在本文表征的时间段内（室温下45天）没有表现出信号漂移或滞后。我们将传感器转换成生物电子射频识别标签，通过一个单一的LED连接，这些远程报告葡萄糖浓度通过发射光。我们预期RF读出和基于苯基硼酸的水凝胶的非降解、长期性质将使生物传感器能够长期、远程读出葡萄糖。
A phenylboronic acid-based, hydrogel-interlayer Radio-Frequency (RF) resonator is demonstrated as a highly-responsive, passive and wireless sensor for glucose monitoring. Constructs are composed of unanchored, capacitively-coupled split rings interceded by glucose-responsive hydrogels. Phenylboronic acid-hydrogels exhibit volumetric and dielectric variations in response to environmental glucose concentrations-these are efficiently converted to large shifts in the resonant response of interlayer-RF sensors. These tiny, stretchable and scalable sensors (5 mm x 5 mm x 250 mu m) require no microelectronics or power at the sensing node and can be read-out remotely via near-field coupling. Sensors exhibit high sensitivities (similar to 10% shift in resonant frequency-corresponding to 50 MHz-per 150 mg/dL of glucose), possess a limit of detection of 10 mg/dL, and a step response time of approximately 1 h to abrupt shifts in carbohydrate concentration. Notably, these sensors exhibited no signal drift or hysteresis over the time periods characterized herein (45 days at room temperature). We transform sensors into bioelectronic RF reporter-tags via the attachment of a single LED-these remotely report on glucose concentration via emitted light. We anticipate the non-degradative, long-term nature of both RF read-out and phenylboronic acid-based hydrogels will enable biosensors capable of long-term, remote read-out of glucose.