Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis
Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis
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DOI：
10.1073/pnas.0712019105
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发表时间：
2008-09-30
影响因子：
11.1
通讯作者：
Maiden, Martin C. J.
中科院分区：
文献类型：
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作者：
Buckee, Caroline O.;Jolley, Keith A.;Maiden, Martin C. J.
脑膜炎奈瑟菌是一种人类共生细菌，偶尔会引起危及生命的疾病。与许多其他细菌性病原体一样，脑膜炎球菌种群包含不同的谱系，在面临高重组率的全球传播过程中持续存在数十年。此外，引起侵袭性疾病的倾向与特定的“高侵袭性”谱系相关联，这些谱系与低侵袭性谱系共存，尽管事实上疾病并不促进宿主间传播。在这里，通过将建模方法与来自捷克共和国27年来分离的1108种脑膜炎球菌的分子流行病学数据相结合，我们表明，由免疫选择介导的菌株间竞争可以解释多种离散脑膜炎球菌谱系的持续存在以及其中一部分与侵袭性疾病的关联。该模型表明，定义这些谱系的管家基因的等位变异组合与宿主之间传播效率的非常小的差异有关。这些发现对重组细菌种群的谱系结构和毒力的出现具有普遍意义。
Neisseria meningitis is a human commensal bacterium that occasionally causes life-threatening disease. As with a number of other bacterial pathogens, meningococcal populations comprise distinct lineages, which persist over many decades and during global spread in the face of high rates of recombination. In addition, the propensity to cause invasive disease is associated with particular "hyperinvasive'' lineages that coexist with less invasive lineages despite the fact that disease does not contribute to host-to-host transmission. Here, by combining a modeling approach with molecular epidemiological data from 1,108 meningococci isolated in the Czech Republic over 27 years, we show that interstrain competition, mediated by immune selection, can explain both the persistence of multiple discrete meningococcal lineages and the association of a subset of these with invasive disease. The model indicates that the combinations of allelic variants of housekeeping genes that define these lineages are associated with very small differences in transmission efficiency among hosts. These findings have general implications for the emergence of lineage structure and virulence in recombining bacterial populations.