Neurobehavioral disturbances arising from occupational toluene exposure.
Neurobehavioral disturbances arising from occupational toluene exposure.
复制标题
职业性甲苯暴露引起的神经行为障碍。
DOI：
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复制
发表时间：
2002
影响因子：
3.5
通讯作者：
Marie
中科院分区：
文献类型：
--
作者：
D. Chouanière;P. Wild;J. Fontana;M. Héry;M. Fournier;V. Baudin;I. Subra;D. Rousselle;J. Toamain;S. Saurin;Marie
背景
已知长期接触甲苯的神经毒性水平高于50 ppm，怀疑在较低水平。
方法
在两个印刷厂对129名蓝领工人进行了一项横断面研究，探讨了这种低水平的甲苯暴露。使用231个环境空气样本，工厂A（偏移）中的甲苯浓度估计为0至18 ppm，工厂B（凹版印刷）中的甲苯浓度估计为2至27 ppm。在任何急性暴露期之外，工人回答了关于神经毒性症状的自我管理问卷EUROQUEST，并在计算机辅助版本的电池内斯上进行了六次心理测量测试。
结果
在调整混杂因素后，我们发现仅当前暴露与数字跨度向前（DSF）性能（40 ppm时减少1位，P=0.04）和数字跨度向后（DSB）性能（25 ppm时减少1位，P=0.01）之间存在显著关系。神经毒性症状与当前暴露无显著相关性。估计的累积暴露量与心理测量表现或神经毒性症状之间没有关联。
结论
在这项研究中，目前暴露于甲苯的低水平与记忆测试性能的下降。
BACKGROUND
Neurotoxicity of long-term exposure to toluene is known at higher levels than 50 ppm and is suspected at lower levels.
METHODS
A cross-sectional study carried out in two printing plants on 129 blue collar workers explored such a low level exposure of toluene. With 231 samples of ambient air, toluene concentration was estimated from 0 to 18 ppm in Plant A (offset) and from 2 to 27 ppm in Plant B (heliogravure). Outside any period of acute exposure, the workers answered a self-administered questionnaire on neurotoxic symptoms, EUROQUEST, and performed six psychometric tests on a computer-assisted version of battery NES.
RESULTS
After adjustment for confounders, we found significant relationships only between present exposure and Digit Span Forwards (DSF) performance (decrement is 1 digit for 40 ppm, P=0.04) and Digit Span Backwards (DSB) performance (decrement is 1 digit for 25 ppm, P=0.01). Neurotoxic symptoms were not significantly correlated with current exposure. No association was found between estimated cumulative exposure and either psychometric performances or neurotoxic symptoms.
CONCLUSION
In this study, low present exposure levels to toluene were associated with decrements of memory test performances.
NES2 在神经系统疾病患者中的验证。
影响因子：
2.9
作者：
White,RF;Diamond,R;Krengel,M;Lindem,K;Feldman,RG;Letz,R;Eisen,E;Wegman,D
通讯作者：
Wegman,D
接触甲苯时的人类表现。
DOI：
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发表时间：
1996
期刊：
Aviation, space, and environmental medicine
影响因子：
--
作者：
Rahill,AA;Weiss,B;Morrow,PE;Frampton,MW;Cox,C;Gibb,R;Gelein,R;Speers,D;Utell,MJ
通讯作者：
Utell,MJ