ALTERATIONS IN CATECHOLAMINE NEURONS OF THE LOCUS COERULEUS IN SENILE DEMENTIA OF THE ALZHEIMER TYPE AND IN PARKINSONS-DISEASE WITH AND WITHOUT DEMENTIA AND DEPRESSION
ALTERATIONS IN CATECHOLAMINE NEURONS OF THE LOCUS COERULEUS IN SENILE DEMENTIA OF THE ALZHEIMER TYPE AND IN PARKINSONS-DISEASE WITH AND WITHOUT DEMENTIA AND DEPRESSION
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DOI：
10.1002/cne.902870308
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发表时间：
1989-09-15
影响因子：
2.5
通讯作者：
ASAN, E
中科院分区：
文献类型：
--
作者：
CHANPALAY, V;ASAN, E
本研究对阿尔茨海默型老年痴呆（SDAT）和帕金森病（PD）的蓝斑（LC）去甲肾上腺素（NE）神经元进行了定性和定量研究。PD受试者组被细分为无痴呆病例（P-D），痴呆病例，L-多巴反应性（P + D），以及运动障碍症状为L-多巴无反应的暴发性痴呆病例（P + D/L-多巴无反应）。酪氨酸羟化酶（TH）免疫细胞化学染色显示NE神经元。神经元参数和细胞数量的定量和三维重建的LC进行了计算机辅助系统。在SDAT病例中，LC的吻尾长度（13 . ±. 2.2 mm）短于对照组（14.9 ±. 1.4 mm）。在正常人脑中发现的四种基本LC神经元类别（大多极、大“双极”、小多极和小“双极”神经元; Chan-Palay和Asan：J.Comp.Neurol.这个问题）是可识别的，但许多细胞胞体肿胀和畸形，具有缩短，厚，分支较少的树突。LC神经元数量减少（在-3.5%和-87.5%之间）。神经元的损失是最大的吻部，较少的中间，最少的尾部。在PD病例中，喙尾长度（12.4 ±. 1.5 mm）短于SDAT和对照。神经元形态学改变比SDAT更严重。基本的神经元类别很难区分。大多数细胞体肿胀，经常含有路易体，树突短而薄，缺乏或减少分支。神经元数量比SDAT中减少更多（在-26.4%和-94.4%之间）。在P-D和P+D/L-多巴无反应病例中，尾侧和喙侧的改变同样严重。P+D病例的喙部受影响更严重。SDAT和帕金森病患者中抑郁的存在伴随着LC神经元的最大损失。根据TH-免疫反应神经元的形态学改变以及神经元丢失的程度和地形分布，可以将正常脑中的LC与SDAT和PD中的LC区分开来，以用于诊断目的。
The present study provides qualitative and quantitative investigations of the norepinephrine (NE) neurons is the locus coeruleus (LC) in two neurode-generative disorders, the senile dementia of the Alzheimer type (SDAT) and Parkinson''s disease (PD). The group of PD subjects was subdivided into cases without dementia (P-D), cases with dementia, L-dopa responsive (P + D), and cases with fulminant dementia whose motor disorder symptoms were L-dopa nonresponsive (P + D/L-dopa non-responsive). NE neurons were demonstrated by immunocytochemistry against tyrosine hydroxylase (TH). Quantitations of neuronal parameters and cell numbers and three-dimensional reconstructions of the LC were carried out with a computer-assisted system. In SDAT cases, the rostrocaudal LC length (13 .+-. 2.2 mm) is shorter than in controls (14.9 .+-. 1.4 mm). The four basic LC neuron classes found in the normal human brain (large multipolar, large "bipolar," small multipolar, and small "bipolar" neurons; Chan-Palay and Asan: J. Comp. Neurol. this issue) are recognizable, but many cell somata are swollen and misshapen with foreshortened, thick, and less branched dendrites. LC neuron numbers are reduced (between-3.5% and -87.5%). Neuron loss is greatest in the rostral part, less in the middle, and least in the caudal part. In PD cases, the rostrocaudal length (12.4 .+-. 1.5 mm) is shorter than in SDAT and controls. The neuronal morphology is more severely altered that in SDAT. The basic neuron classes are hardly distinguishable. Most cell bodies are swollen; they frequently contain Lewy bodies; and the dendrites are short and thin with absent or reduced arborizations. Neuron numbers are more reduced than in SDAT (between -26.4% and -94.4%). Alterations are as severe caudally as rostrally in P-D, and P+D/L-dopa nonresponsive cases. P+D cases are more severely affected rostrally. The presence of depression in SDAT and Parkinson''s patients is accompanied by the greatest loss of LC neurons. On the basis of morphological alterations of the TH-immunoreactive neurons, and the degree and topographical distribution of neuron loss, a differentiation is possible between the LC in normal brain and that in SDAT and PD for diagnostic purposes.