Antimalarial activity of extracts of Malaysian medicinal plants
Antimalarial activity of extracts of Malaysian medicinal plants
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DOI：
10.1016/s0378-8741(98)00135-4
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发表时间：
1999-03-01
影响因子：
5.4
通讯作者：
Ali Mohd, M
中科院分区：
文献类型：
--
作者：
Rahman, NNNA;Furuta, T;Ali Mohd, M
体外和体内研究表明，马来西亚的药用植物，胡椒、穿心莲和青牛胆具有相当大的抗疟作用。氯仿提取物的体外抑菌效果优于甲醇提取物。氯仿提取物在24小时的孵育期内显示出完全的寄生虫生长抑制，低至0.05 mg/ml的药物剂量（穿心莲），而甲醇提取物的药物剂量为2.5 mg/ml，但孵育时间为48小时。穿心莲的体内抗疟活性也高于其它两种植物。(C)1999由Elsevier Science爱尔兰有限公司出版。保留所有权利。
In vitro and in vivo studies revealed that Malaysian medicinal plants, Piper sarmentosum, Andrographis paniculata and Tinospora crispa produced considerable antimalarial effects. Chloroform extract in vitro did show better effect than the methanol extract. The chloroform extract showed complete parasite growth inhibition as low as 0.05 mg/ml drug dose within 24 h incubation period (Andrographis paniculata) as compared to methanol extract of drug dose of 2.5 mg/ml but under incubation time of 48 h of the same plant spesies. In vivo activity of Andrographis paniculata also demonstrated higher antimalarial effect than other two plant species. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.