Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
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DOI：
10.1073/pnas.1002307107
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发表时间：
2010-04-06
影响因子：
11.1
通讯作者：
Suedhof, Thomas C.
中科院分区：
文献类型：
--
作者：
Mukherjee, Konark;Yang, Xiaofei;Suedhof, Thomas C.
短笛和巴松管是突触前细胞基质中高度同源的多结构域蛋白，其功能尚不清楚。在这里，我们产生了短笛敲入/敲除小鼠，其含有野生型水平的不能结合Ca 2+的突变短笛（敲入），类似于C末端截短的短笛（部分敲除）水平降低60%，或者
Piccolo and bassoon are highly homologous multidomain proteins of the presynaptic cytomatrix whose function is unclear. Here, we generated piccolo knockin/knockout mice that either contain wildtype levels of mutant piccolo unable to bind Ca2+ (knockin), similar to 60% decreased levels of piccolo that is C-terminally truncated (partial knockout), or