Capsaicin-resistant vagal afferent fibers in the rat gastrointestinal tract: Anatomical identification and functional integrity
Capsaicin-resistant vagal afferent fibers in the rat gastrointestinal tract: Anatomical identification and functional integrity
复制标题
DOI：
10.1016/s0006-8993(96)01222-x
复制
发表时间：
1997-01-23
期刊：
影响因子：
2.9
通讯作者：
Neuhuber, WL
中科院分区：
文献类型：
--
作者：
Berthoud, HR;Patterson, LM;Neuhuber, WL
迷走神经纤维和终端的存在和分布在整个食管和胃肠道，可以顺行标记的结状神经节示踪剂注射定量评估辣椒素和车辆预处理的成年大鼠，以确定辣椒素耐药的人口。食管肌间神经丛中高达90%的神经节内层状末梢（IGLE）和胃中70-90%的IGLE以及胃底中57%的肌内末梢或阵列（IMA）在辣椒素处理后存活，而在小肠上部只有少数，在小肠下部、盲肠和结肠中，几乎没有IGLE在辣椒素处理后存活。未评估粘膜内末端。此外，胃球囊扩张诱导的c-Fos在背迷走神经复合体的表达并没有显着降低辣椒素治疗的大鼠。它的结论是，在初级迷走神经传入有一个辣椒素耐药的人口，主要支配食管和上消化道，和辣椒素敏感的人口，主要支配下道。至少迷走神经胃张力敏感传入似乎也是功能完整的，因为它们可能能够突触激活脑干中的二级神经元。
The presence and distribution of vagal fibers and terminals throughout esophagus and gastrointestinal tract that could be anterogradely labeled by nodose ganglion tracer injections was quantitatively assessed in capsaicin- and vehicle-pretreated adult rats, in order to identify the capsaicin-resistant population. Up to 90% of the intraganglionic laminar endings (IGLEs) in the myenteric plexus of the esophagus, and 70-90% in the stomach, as well as 57% of the intramuscular endings or arrays (IMAs) in the fundic stomach survived the capsaicin treatment, while in the upper small intestine only few and in the lower small intestine, the cecum and colon, virtually no IGLEs survived capsaicin treatment. Intramucosal terminals were not assessed. Furthermore, gastric balloon distension-induced c-Fos expression in the dorsal vagal complex was not significantly decreased in capsaicin-treated rats. It is concluded that among primary vagal afferents there is a capsaicin-resistant population that primarily innervates the esophagus and upper gastrointestinal tract, and a capsaicin-sensitive population that innervates mainly the lower tract. At least vagal gastric tension-sensitive afferents also seem to be functionally intact in that they may be capable of synaptically activating second-order neurons in the brainstem.