Language, executive function and social cognition in the diagnosis of frontotemporal dementia syndromes.
Language, executive function and social cognition in the diagnosis of frontotemporal dementia syndromes.
复制标题
语言，执行功能和社会认知在诊断额颞痴呆综合征的诊断中。
DOI：
10.3109/09540261.2013.763340
复制
发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Cosentino S
中科院分区：
文献类型：
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作者：
Harciarek M;Cosentino S
额颞叶痴呆（FTD）代表一系列与额叶和/或颞叶局灶性萎缩相关的非阿尔茨海默病退行性疾病。大脑的额叶和颞区已被证明与执行功能、社会认知和语言处理密切相关，因此，这些区域的缺陷经常见于FTD患者，甚至可能是特定FTD亚型的标志（即，原发性进行性失语中的相对选择性和进行性语言障碍）。在这篇综述中，我们试图描述语言、执行功能和社会认知如何有助于FTD综合征的诊断，即行为变体FTD以及FTD的语言变体，包括原发性进行性失语症（PPA）的三种亚型：非流利/语法、语义和逻辑缺失。本综述还讨论了这些认知领域的缺陷在何种程度上有助于FTD与AD的鉴别诊断。最后，病理学的早期临床决定因素进行了简要讨论，并提出了诊断FTD的当代挑战。
Frontotemporal dementia (FTD) represents a spectrum of non-Alzheimer’s degenerative conditions associated with focal atrophy of the frontal and/or temporal lobes. Frontal and temporal regions of the brain have been shown to be strongly involved in executive function, social cognition and language processing and, thus, deficits in these domains are frequently seen in patients with FTD or may even be hallmarks of a specific FTD subtype ( i.e., relatively selective and progressive language impairment in primary progressive aphasia). In this review, we have attempted to delineate how language, executive function, and social cognition may contribute to the diagnosis of FTD syndromes, namely the behavioral variant FTD as well as the language variants of FTD including the three subtypes of primary progressive aphasia (PPA): non-fluent/agrammatic, semantic, and logopenic. This review also addresses the extent to which deficits in these cognitive areas contribute to the differential diagnosis of FTD versus AD. Finally, early clinical determinants of pathology are briefly discussed and contemporary challenges to the diagnosis of FTD are presented.