Overactivation of fear systems to neutral faces in schizophrenia
Overactivation of fear systems to neutral faces in schizophrenia
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DOI：
10.1016/j.biopsych.2007.12.014
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发表时间：
2008-07-01
影响因子：
10.6
通讯作者：
Lawrie, Stephen M.
中科院分区：
文献类型：
--
作者：
Hall, Jeremy;Whalley, Heather C.;Lawrie, Stephen M.
背景：杏仁核在检测和响应与恐惧相关的刺激中起着核心作用。最近的一些研究报告说，与匹配的中性刺激（如中性面孔）相比，精神分裂症患者的杏仁核对情绪刺激（如恐惧面孔）的激活减少。我们调查了精神分裂症患者杏仁核激活的明显减少是否实际上是由于杏仁核对中性比较物stimulation.Methods：19名精神分裂症患者和24名匹配的对照参与者在功能性磁共振成像扫描期间观看了具有恐惧或中性面部表情的面部照片。与中性面孔相比，精神分裂症患者对恐惧面孔的杏仁核激活相对减少。然而，这种差异导致杏仁核激活的增加，精神分裂症患者的中性面孔，而不是从减少反应的恐惧faces.Conclusions：精神分裂症患者表现出增加的杏仁核反应的中性面孔。这足以解释他们在面对恐惧面孔时杏仁核激活的明显缺陷。涉及恐惧的神经系统对其他中性刺激的不适当激活可能有助于精神分裂症中精神病性症状的发展。
Background: The amygdala plays a central role in detecting and responding to fear-related stimuli. A number of recent studies have reported decreased amygdala activation in schizophrenia to emotional stimuli(such as fearful faces) compared with matched neutral stimuli (such as neutral faces). We investigated whether the apparent decrease in amygdala activation in schizophrenia could actually derive from increased amygdala activation to the neutral comparator stimuli.Methods: Nineteen patients with schizophrenia and 24 matched control participants viewed pictures of faces with either fearful or neutral facial expressions, and a baseline condition, during functional magnetic resonance imaging scanning.Results: Patients with schizophrenia showed a relative decrease in amygdala activation to fearful faces compared with neutral faces. However, this difference resulted from an increase in amygdala activation to the neutral faces in patients with schizophrenia, not from a decreased response to the fearful faces.Conclusions: Patients with schizophrenia show an increased response of the amygdala to neutral faces. This is sufficient to explain their apparent deficit in amygdala activation to fearful faces compared with neutral faces. The inappropriate activation of neural systems involved in fear to otherwise neutral stimuli may contribute to the development of psychotic symptoms in schizophrenia.