NITROGEN-DIOXIDE INDUCED CHANGES IN LEVEL OF FREE FATTY-ACIDS, TRIGLYCERIDE, ESTERIFIED FATTY-ACID, GANGLIOSIDE AND LIPASE ACTIVITY IN THE GUINEA-PIG BRAIN
NITROGEN-DIOXIDE INDUCED CHANGES IN LEVEL OF FREE FATTY-ACIDS, TRIGLYCERIDE, ESTERIFIED FATTY-ACID, GANGLIOSIDE AND LIPASE ACTIVITY IN THE GUINEA-PIG BRAIN
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DOI：
10.1080/03601239209372767
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发表时间：
1992-01-01
影响因子：
2
通讯作者：
HASAN, M
中科院分区：
文献类型：
--
作者：
FARAHANI, H;HASAN, M
本文观察了18只雄性豚鼠对控制性吸入二氧化氮（NO_2）的生化反应。将动物暴露于2.5、5.0和10 ppm的NO2中，每天2h，连续35天，并将结果与6只对照动物暴露于过滤空气中，每天2h，连续35天进行比较。在暴露的最后一天后立即测定了五项生化指标，包括甘油三酯、游离脂肪酸、酯化脂肪酸、神经节苷脂和脂肪酶活性。而当剂量浓度增加至5和10 ppm二氧化氮时，在豚鼠CNS不同区域的甘油三酯、游离脂肪酸、酯化脂肪酸、神经节苷脂和脂肪酶活性水平中观察到显著的剂量相关变化。
The biochemical response to controlled inhalation of nitrogen dioxide (NO2) was studied in 18 male guinea pigs. Animals were exposed to 2.5, 5.0, and 10 ppm No2 for 2h daily for 35 consecutive days, and the results compared with six control animals exposed to filtered air for 2h daily for same period. Five biochemical parameters, including triglyceride, free fatty acids, esterified fatty acid, ganglioside and lipase activity were measured immediately after the last day of exposure.At 2.5 ppm NO2 inhalation no significant changes occurred in any region of the central nervous system (CNS). While as the dose concentration was increased to 5 and 10 ppm nitrogen dioxide, significant dose-related alteration were observed in the levels of triglyceride, free fatty acid, esterified fatty acid, ganglioside and lipase activity in the different regions of the guinea pig CNS.