Abnormal resting-state functional connectivity study in unilateral pulsatile tinnitus patients with single etiology: A seed-based functional connectivity study
Abnormal resting-state functional connectivity study in unilateral pulsatile tinnitus patients with single etiology: A seed-based functional connectivity study
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DOI：
10.1016/j.ejrad.2016.09.011
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发表时间：
2016-11-01
影响因子：
3.3
通讯作者：
Wang Zhenchang
中科院分区：
文献类型：
--
作者：
Lv Han;Zhao Pengfei;Wang Zhenchang
目的：已有研究表明脉冲性耳鸣(PT)患者多个脑区的局部神经活动发生改变，尤其是后扣带回(PCC)在其中起着重要作用。然而，很少有研究关注PT患者这一区域的功能连接(FC)程度。在这项研究中，我们将利用静息状态功能磁共振成像(FMRI)比较患有这种疾病的患者和正常对照组的PCC的FC。方法：收集36例单侧单侧PT患者和36例匹配的健康对照组的结构和功能MRI数据。结果：与健康对照组相比，患者右侧颞中回、右侧丘脑和双侧脑岛的FC明显降低。相比之下，PCC显示楔前叶、双侧顶下小叶和枕中回之间的功能连接增加。PT的病程与右侧PCCMTG的FC呈正相关(r=0.616，p<；0.001)。结论：单侧PT患者可出现双侧脑内对PCC的FC异常。PCC作为一个高度整合的大脑区域，是参与不同神经网络之间中介作用的一个例子。它可能是视觉网络和听觉网络之间的调制核心。MTG对PCC的Fc降低可能提示了PCC与听觉相关大脑皮层之间的活动下调。边缘系统(双侧AI)和PCC之间的FC降低可能反映了患者组的情绪信息控制。这项研究有助于了解搏动性耳鸣患者潜在的神经病理过程。(C)2016爱思唯尔爱尔兰有限公司。保留所有权利。
Objective: Previous studies demonstrated altered regional neural activations in several brain areas in patients with pulsatile tinnitus (PT), especially indicating an important role of posterior cingulate cortex (PCC). However, few studies focused on the degree of functional connectivity (FC) of this area in PT patients. In this study, we will compare the FC of PCC in patients affected with this condition and normal controls by using resting-state functional magnetic resonance imaging (fMRI).Methods: Structural and functional MRI data were obtained from 36 unilateral PT patients with single etiology and 36 matched healthy controls. FC feature of the region of interest (PCC) were characterized using a seed-based correlation method with the voxels in the whole-brain.Results: Compared with healthy controls, patients showed significant decreased FC to the right middle temporal gyrus (MTG), right thalamus and bilateral insula. By contrast, PCC demonstrated increased functional connectivity between the precuneus, bilateral inferior parietal lobule and middle occipital gyrus. We also found correlations between the disease duration of PT and FC of PCC-right MTG (r = 0.616, p < 0.001).Conclusions: Unilateral PT patients could have abnormal FC to the PCC bilaterally in the brain. PCC, as a highly integrated brain area, is an example of nucleus that was involved in mediation between different neural networks. It might be a modulation core between visual network and auditory network. The decreased FC of MTG to PCC may indicate a down regulation of activity between PCC and auditory associated brain cortex. Decreased FC between limbic system (bilateral AI) and PCC may reflect the emotional message control in patient group. This study facilitated understanding of the underlying neuropathological process in patients with pulsatile tinnitus. (C) 2016 Elsevier Ireland Ltd. All rights reserved.