Nitrone protecting groups for enantiopure N-hydroxyamino acids: synthesis of N-terminal peptide hydroxylamines for chemoselective ligations.
Nitrone protecting groups for enantiopure N-hydroxyamino acids: synthesis of N-terminal peptide hydroxylamines for chemoselective ligations.
复制标题
对映体纯 N-羟基氨基酸的硝酮保护基团：用于化学选择性连接的 N 末端肽羟胺的合成。
DOI：
10.1039/c004490c
复制
发表时间：
2010
影响因子：
3.2
通讯作者：
Bode,JeffreyW
中科院分区：
文献类型：
--
作者：
Medina,SIrene;Wu,Jian;Bode,JeffreyW
The synthesis of enantiopure N-benzylidene nitrones of N-hydroxy-α-amino acids and their incorporation using standard Fmoc-based peptide chemistry into solid-supported peptide chains is described. Deprotection and resin cleavage affords N-terminal peptide hydroxylamines, which are the key substrates for chemoselective ligations with C-terminal peptide α-ketoacids. This general route is applicable to a variety of different N-terminal residues and provides a general approach to the solid phase synthesis of peptide hydroxylamines.
