The heterotopic effects of insulin and glucagon on the acinar activity pattern of phosphoenolpyruvate carboxykinase in male and female rat liver.
The heterotopic effects of insulin and glucagon on the acinar activity pattern of phosphoenolpyruvate carboxykinase in male and female rat liver.
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胰岛素和胰高血糖素对雄性和雌性大鼠肝脏中磷酸烯醇丙酮酸羧激酶腺泡活性模式的异位效应。
DOI：
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
M. Colombi
中科院分区：
文献类型：
--
作者：
M. Wimmer;C. Luttringer;M. Colombi
本文研究了胰岛素和胰升糖素对雄性和雌性大鼠肝脏腺泡内磷酸烯醇式丙酮酸羧激酶(PEPCK)异位性的影响。无论是男性还是女性，胰岛素对PEPCK活性或其腺泡分布均无显著影响。但对葡萄糖-6-磷酸脱氢酶和苹果酸酶的活性有影响。超生理浓度的胰升糖素可诱导PEPCK活性。尽管胰升糖素在整个肝窦内的浓度较高，但在门静脉周围和腺泡的中间部，其诱导作用最为明显，表明局部的胰升糖素浓度与PEPCK活性之间没有直接的相互关系。在这两个实验中，血糖水平都保持相当稳定。
The effects of the administration of insulin and glucagon on the intraacinar heterotopy of phosphoenolpyruvate carboxykinase (PEPCK) were investigated in male and female rat liver. Insulin did not noticeably influence PEPCK activity or its acinar distribution, either in males or in females. But it affected the activities of glucose-6-phosphate dehydrogenase and malic enzyme. Glucagon in supraphysiological concentrations led to an induction of PEPCK activity. Despite high glucagon concentration along the whole sinusoidal length, the inducing effect of glucagon was most pronounced in the periportal and intermediary parts of the acinus; thus indicating that there is no direct interrelationship between local glucagon concentration and PEPCK activity. In both experiments blood glucose levels were kept fairly constant.
胰岛素和 cAMP 对磷酸烯醇丙酮酸羧激酶基因转录的调节：起始和延伸的相互作用。
DOI：
10.1073/pnas.85.9.2954
发表时间：
1988
影响因子：
11.1
作者：
Sasaki,K;Granner,DK
通讯作者：
Granner,DK
胰岛素和胰高血糖素对大鼠肝脏中磷酸烯醇丙酮酸羧激酶 (GTP) mRNA 水平的调节。
DOI：
10.1016/0065-2571(81)90016-9
发表时间：
1980
期刊：
Advances in enzyme regulation
影响因子：
--
作者：
Cimbala,MA;vanLelyveld,P;Hanson,RW
通讯作者：
Hanson,RW