HLA-class II alleles in egyptian patients with hepatocellular carcinoma
HLA-class II alleles in egyptian patients with hepatocellular carcinoma
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DOI：
10.1080/08820130802111605
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发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Tawhid, Ziyad E.
中科院分区：
文献类型：
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作者：
El-Chennawi, Farha A.;Auf, Fatma A.;Tawhid, Ziyad E.
肝细胞癌（HCC）与环境、饮食和生活方式等因素有关。其发病率和分布在不同种族、性别和地理区域之间差别很大。HBV和HCV感染、肝硬化、男性、年龄是HCC发生的重要危险因素。暴露后结果的可变性，以及HCC在家族中的聚集性，提高了遗传因素也参与HCC易感性的可能性。主要组织相容性复合体（MHC）在抗病毒和肿瘤防御中起着关键作用。HLA多态性与许多免疫介导疾病（包括某些癌症）的遗传易感性有关。HLAⅱ类抗原与HCC在不同民族人群中的相关性一直存在争议。因此，这项工作的目的是研究HLA II-DRB1和DQB1多态性与埃及患者HCC之间的关系，并探讨它们作为HCC发展的危险因素的作用。方法：采用SSP法对100例患者进行hlaⅱ类（DRB1和DQB1）分型；50例HCC患者（男45例，女5例），年龄40 ~ 64岁（51.16岁(y) 6.16）；50名正常健康对照者。结果:1。与对照组相比，HCC患者DRB1*04、DQB1 *02的频率显著增加（p分别为0.016、0.032）；2. DQB1*06的频率显著降低（p = 0.032）；3. DRB1*07的发病频率显著增高（优势比(OR) = 4.929）；和4。DRB1*15的频率显著降低（OR = 0.316）。综上所述，部分等位基因与HCC有显著相关性（DRB1*04, DQB1*02），部分等位基因与HCC无显著相关性（DQB1*06）；因此，DRB1*04和DQB1*02等位基因可能是HCC发生的危险因素（OR分别为4.373和3.807），DQB1*06可能是保护性等位基因（OR = 0.259）。
Hepatocellular carcinoma (HCC) is linked to environmental, dietary, and life style factors. Its incidence and distribution vary widely among ethnic groups, sex, and geographic regions. HBV and HCV Infection, liver cirrhosis, male gender, and old age are important risk factors of HCC. Variability in outcome following exposure, and the clustering of HCC within families raise the possibility that genetic factors are also involved in susceptibility to HCC. The Major Histocompatibility Complex (MHC) plays a key role in anti-virus and tumor defense. HLA polymorphism is implicated in conferring genetic susceptibility to a large number of immune-mediated diseases, including some cancers. The association between HLA class II antigen and HCC in different ethnic populations that has been reported is controversial. Therefore, the aim of this work was to study the association between HLA class II-DRB1 and DQB1 polymorphism and HCC in Egyptian patients and to investigate their role as risk factors for the development of HCC. Methods: HLA-class II (DRB1 and DQB1) typing was done by SSP for 100 subjects; 50 patients suffering from HCC (45 males and 5 females) with age range 40-64 years (51.16 years (y) 6.16); and 50 normal healthy control subjects. Results: 1. A significantly increased frequency of DRB1*04, and DQB1 *02 in HCC patients versus control group (p = 0.016, and 0.032, respectively) was found; 2. A significantly decreased frequency of DQB1*06 (p = 0.032) was found; 3. A significantly increased frequency of DRB1*07 (odds ratio (OR) = 4.929) was found; and 4. A significantly decreased frequency of DRB1*15 (OR = 0.316) was seen. In conclusion, while some alleles are significantly associated with HCC (DRB1*04, DQB1*02) and others are not associated (DQB1*06); therefore, it can be concluded that the DRB1*04 and DQB1*02 alleles might be risk factors for the occurrence of HCC (OR = 4.373 and 3.807, respectively), and DQB1*06 may be a protective allele (OR = 0.259).