New compounds from the aerial parts of Calligonum mongolicum
New compounds from the aerial parts of Calligonum mongolicum
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DOI：
10.1016/j.phytol.2020.12.002
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发表时间：
2021-02-01
影响因子：
1.7
通讯作者：
Sasaki, Kenroh
中科院分区：
文献类型：
--
作者：
Buyankhishig, Buyanmandakh;Murata, Toshihiro;Sasaki, Kenroh
从沙拐枣地上部分分离得到未曾报道的化合物(R)-4-(4-羟基苯基)-2-丁醇-2-O-(6-O-没食子酸)-β-D-吡喃葡萄糖苷(1)和(E)-5-(4-羟基苯基)对-2-烯酸(2)，以及20个已知化合物(3-22)。化合物3为首次从天然资源中分离得到，所有化合物(1 2 2)均为首次报道。化合物1和2的结构主要通过HRFABMS、HREIMS、(1)Hand C-13核磁共振、H-1-H-1 COSY、HMQC和HMBC谱进行了确证。结果表明，儿茶素(7)的酚氧化酶抑制活性(IC(50)9.1muM)是表儿茶素(8)的10倍(IC50为148.3µM)。除了它们的立体化学外，化合物7和8有一个共同的分子结构，这一结果得到了使用纯保证正品的重复性测试的支持。
Previously undescribed compounds, (R)-4-(4-hydroxyphenyl)-2-butanol 2-O-(6-O-galloyl)-beta-D-glucopyranoside (1) and (E)-5-(4-hydroxyphenyl)pent-2-enoic acid (2), together with 20 known compounds (3-22) were isolated from the aerial parts of Calligonum mongolicum. Compound 3 was obtained from a natural source for the first time, and all of the compounds (1 22) were reported for the first time in this plant. The structural elucidation of compounds 1 and 2 were performed mainly by HRFABMS, HREIMS, (1)Hand C-13 NMR, H-1-H-1 COSY, HMQC, and HMBC spectroscopy. Some of the enzyme inhibitory activities of the isolated compounds were estimated, and catechin (7) showed ten times higher phenoloxidase inhibitory activity (IC(50 )9.1 mu M) than epicatechin (8) (IC50 148.3 mu M). Compounds 7 and 8 have a common molecular structure, except for their stereochemistry, and this result was supported by a reproducibility test using pure guaranteed authentic samples.