Dopamine detection on activated reaction field consisting of graphene-integrated silicon photonic cavity
Dopamine detection on activated reaction field consisting of graphene-integrated silicon photonic cavity
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DOI：
10.1364/oe.27.032058
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发表时间：
2019-10-28
期刊：
影响因子：
3.8
通讯作者：
Yamada, Koji
中科院分区：
文献类型：
--
作者：
Kou, Rai;Kobayashi, Yuzuki;Yamada, Koji
石墨烯被广泛认为是电子、光子、机械和生命科学等各个应用领域的杰出多功能材料。我们提出了一种超小体积的神经递质传感器，用于检测光子光物质响应。这种检测可以使用表面激活的单层石墨烯片和 CMOS 兼容的硅光子电路来实现。 CVD 生长的石墨烯图案片集成在硅微环谐振器的顶部，这会诱导源自 π 堆积效应的儿茶酚胺分子的吸附。我们使用多巴胺来证明这种检测并检查石墨烯-多巴胺偶联的敏感性。为了避免石墨烯在近红外区域极高的光学吸收系数导致的高光学插入损耗和谐振特性劣化，采用了具有调整耦合设计的环形谐振器来弥补这些缺点。得益于先进的纳米传感平台和测量系统，仅约30μm(2)/ch的活化石墨烯传感表面能够以足够的灵敏度与多巴胺进行π耦合，以检测小于10μM的溶液浓度。通过表面反应的检测机制也通过光学模拟和原子力显微镜测量得到验证，揭示流动的多巴胺分子只能占据石墨烯的最外层表面。我们期望该传感器能够为开发具有准确、灵敏和快速响应的创新型无标签一次性生物传感平台做出贡献。 (C) 2019 年美国光学学会根据 OSA 开放获取出版协议条款
Graphene is widely recognized as an outstanding and multi-functional material in various application fields such as electronics, photonics, mechanics, and life sciences. We propose a neurotransmitter sensor with ultra-small volume for detecting the photonic light-matter response. Such detection can be achieved using surface-activated monolayer graphene sheets and CMOS-compatible silicon-photonic circuits. Patterned pieces of CVD-grown graphene are integrated on the top of a silicon micro-ring resonator, which induce the adsorption of catecholamine molecules originated from the pi-stacking effect. We used dopamine to demonstrate such detection and examine the sensitivity of graphene-dopamine coupling. To avoid high optical insertion loss and degradation of resonance characteristics caused by a graphene's extremely high optical absorption coefficient in the near infrared region, a ring resonator with adjusted coupling design is used to compensate for the drawbacks. Owing to the advanced nano-sensing platform and measurement system, an activated graphene-sensing surface of only similar to 30 mu m(2)/ch enables pi coupling to dopamine with enough sensitivity to detect less than 10-mu M solution concentration. The detection mechanism through the surface reaction is also verified by optical simulation and atomic force microscopy measurement, revealing that the flowing dopamine molecules can only occupy the outermost surface of graphene. We expect this sensor to contribute to the development of an innovative label-free and disposable bio-sensing platform with accurate, sensitive, and fast response. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement