Nicotine effects on affective response in depression-prone smokers.
Nicotine effects on affective response in depression-prone smokers.
复制标题
尼古丁对有抑郁倾向的吸烟者的情感反应有影响。
DOI：
10.1007/s00213-007-0977-7
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发表时间：
2008
影响因子：
3.4
通讯作者：
Hedeker,Donald
中科院分区：
文献类型：
--
作者：
Spring,Bonnie;Cook,JessicaWerth;Appelhans,Bradley;Maloney,Anne;Richmond,Malia;Vaughn,Jocelyn;Vanderveen,Joseph;Hedeker,Donald
吸烟和抑郁症之间的共病被认为是因为有抑郁倾向的吸烟者自我管理尼古丁来改善情绪。然而，很少有证据支持这一观点，尼古丁对抑郁症的积极影响不足的影响仍然在很大程度上unstudied.ObjectivesWe假设，（1）尼古丁会消除消极影响，提高积极影响和（2）影响将是更强的吸烟者容易抑郁症，特别是在抑郁状态.Materials and methodsRegular smokers（N= 165）从社区招募：63例无重性抑郁障碍（MDD）病史，61例既往复发但无现患MDD，41例既往和现患MDD。在四个阶段中，参与者在经历消极情绪诱导后或在经历积极情绪诱导时双盲吸烟尼古丁化（NIC+）或去尼古丁化（NIC-）香烟。积极和消极的影响进行了测量，在基线和两个时间点后smoking.ResultsPreviously抑郁的吸烟者表现出积极的情绪反应，积极的情绪诱导吸烟时，尼古丁香烟。尼古丁还增加了抑郁症易感吸烟者积极情绪诱导消除消极情绪的程度。最后，尼古丁恶化的负面情绪感应为所有groups.ConclusionSelf-administering尼古丁的负面情绪反应似乎改善抑郁症倾向的吸烟者的情绪反应一个愉快的刺激。
RationaleComorbidity between cigarette smoking and depression is thought to arise because depression-prone smokers self-administer nicotine to improve mood. Yet little evidence supports this view, and nicotine’s effect on positive affect deficiency in depression remains largely unstudied.ObjectivesWe hypothesized that (1) nicotine would dispel negative affect and enhance positive affect and (2) effects would be stronger for smokers vulnerable to depression, particularly during a depressed state.Materials and methodsRegular smokers (N= 165) were recruited from the community: 63 with no history of major depressive disorder (MDD), 61 with recurrent past but no current MDD, and 41 with both current and past MDD. During four sessions, participants smoked either a nicotinized (NIC+) or denicotinized (NIC−) cigarette double blind after experiencing a negative mood induction or while undergoing a positive mood induction. Positive and negative affects were measured at baseline and at two time points after smoking.ResultsPreviously depressed smokers showed a heightened positive mood response to positive mood induction when smoking a nicotinized cigarette. Nicotine also increased the degree to which positive mood induction dispelled negative mood in depression-vulnerable smokers. Finally, nicotine worsened the negative affect response to negative mood induction for all groups.ConclusionSelf-administering nicotine appears to improve depression-prone smokers’ emotional response to a pleasant stimulus.