GCR2 is a new member of the eukaryotic lanthionine synthetase component C-like protein family
GCR2 is a new member of the eukaryotic lanthionine synthetase component C-like protein family
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DOI：
10.4161/psb.3.5.5292
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Ellis, Brian E.
中科院分区：
文献类型：
--
作者：
Chen, Jin-Gui;Ellis, Brian E.
最近提出GCR2代表植物激素，脱甲酸（ABA）的G蛋白偶联受体（GPCR）。我们和其他人提供的证据表明GCR2不太可能成为真正的GPCR，因为它不能清楚地预测它包含七个跨膜域，这是经典GPCR的结构标志。取而代之的是，GCR2显示出与细菌带合细菌合成酶成分C（LANC）的同源物的显着序列相似性。在这里，我们提供了植物中GCR2和类似Lanc的（LANCL）蛋白的其他分析，并提出GCR2是真核兰克蛋白家族的新成员。
GCR2 was recently proposed to represent a G-protein-coupled receptor (GPCR) for the plant hormone, abscisic acid (ABA). We and others provided evidence that GCR2 is unlikely to be a bona fide GPCR because it is not clearly predicted to contain seven transmembrane domains, a structural hallmark for classical GPCRs. Instead, GCR2 shows significant sequence similarity to homologs of bacterial lanthionine synthetase component C (LanC). Here, we provide additional analysis of GCR2 and LanC-like (LANCL) proteins in plants, and propose that GCR2 is a new member of the eukaryotic LANCL protein family.