No relationship between mean plasma glucose and glycated haemoglobin in patients with cystic fibrosis-related diabetes
No relationship between mean plasma glucose and glycated haemoglobin in patients with cystic fibrosis-related diabetes
复制标题
DOI：
10.1016/j.diabet.2008.05.010
复制
发表时间：
2008-12-01
影响因子：
7.2
通讯作者：
Rabasa-Lhoret, R.
中科院分区：
文献类型：
--
作者：
Godbout, A.;Hammana, I.;Rabasa-Lhoret, R.
目的。 - 随着囊性纤维化（CF）患者预期寿命的延长，囊性纤维化相关糖尿病（CFRD）的患病率急剧增加。糖化血红蛋白 (HbA(1c)) 是监测血糖控制的重要工具，但与 1 型和 2 型糖尿病不同，CF 中 HbA(1c)、果糖胺和平均血浆葡萄糖之间的相关性尚未明确。本研究旨在探讨稳定的 CFRD 患者的平均血糖与 HbA(1c) 或果糖胺之间的关系。方法。 - 15 名 1 型糖尿病患者和 13 名 CFRD 患者（HbA(1c) < 9.0%，无贫血）。与年龄和体重指数（BMI）相匹配，提供了三个月内每月 3 天采集的 72 个毛细血管血糖曲线。最后，测量 HbA(1c) 和果糖胺。使用糖尿病控制和并发症试验 (DCCT) 转换公式估算平均血浆葡萄糖，并进行线性回归以确定其与 HbA(1c) 和果糖胺的关系。结果。 - 在 1 型糖尿病患者中，平均血浆葡萄糖与 HbA(1c) 显着相关（r=0.68；P=0.005）。在CFRD患者中，平均血浆葡萄糖和HbA(1c)之间没有发现相关性（r=0.24：P=0.460）。此外，两组中均未发现平均血浆葡萄糖（代表采血前一个月）与果糖胺之间存在关联。结论。 - 与 1 型糖尿病不同，CFRD 受试者的 HbA(1c) 与平均血浆葡萄糖不相关。因此，HbA(1c) 正常可能不足以表明 CFRD 糖尿病并发症的风险较低。需要进一步的研究来解释这种差异。 (C) 2008 Elsevier Masson SAS。版权所有。
Aim. - Cystic fibrosis-related diabetes (CFRD) prevalence has increased dramatically with the improved life expectancy of patients with cystic fibrosis (CF). Glycated haernoglobin (HbA(1c)) is an important tool for monitoring blood glucose control but, unlike in type 1 and type 2 diabetes, a correlation between HbA(1c), fructosamine and mean plasma glucose has not been clearly established in CF. This study aimed to examine the relationship between mean plasma glucose and HbA(1c) or fructosamine in stable patients with CFRD.Methods. - Fifteen type 1 diabetes and 13 CFRD patients (HbA(1c) < 9.0% no anaemia). matched for age and body mass index (BMI), provided 72 capillary blood glucose profiles taken 3 days/month for three months. At the end of this time, HbA(1c) and fructosamine were measured. Mean plasma glucose was estimated using the Diabetes Control and Complications Trial (DCCT) conversion formula, and linear regressions carried out to establish its relationship with HbA(1c) and fructosamine.Results. - In type 1 diabetes patients, mean plasma glucose correlated significantly with HbA(1c) (r=0.68; P=0.005). In CFRD patients, no correlation was found between mean plasma glucose and HbA(1c) (r=0.24: P=0.460). Also, no association was found between mean plasma glucose, representing the month before blood sampling, and fructosamine in either group.Conclusion. - Unlike in type 1 diabetes, HbA(1c) did not correlate with mean plasma glucose in CFRD subjects. Thus, having a normal HbA(1c) may not be sufficient to indicate a low risk of diabetes complications in CFRD. Further Studies are required to explain such a discrepancy. (C) 2008 Elsevier Masson SAS. All rights reserved.