One-year Outcomes of Pachymetry and Epithelium Thicknesses after Accelerated (45 mW/cm(2)) Transepithelial Corneal Collagen Cross-linking for Keratoconus Patients.
One-year Outcomes of Pachymetry and Epithelium Thicknesses after Accelerated (45 mW/cm(2)) Transepithelial Corneal Collagen Cross-linking for Keratoconus Patients.
复制标题
圆锥角膜患者加速 (45 mW/cm(2)) 跨上皮角膜胶原交联后一年的厚度测量和上皮厚度结果
DOI：
10.1038/srep32692
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发表时间：
2016-09-06
影响因子：
4.6
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Zhang X;Sun L;Chen Y;Li M;Tian M;Zhou X
在这项前瞻性病例系列研究中，评估了加速（45 mW/cm 2）经上皮角膜胶原交联（CXL）治疗圆锥角膜后的角膜厚度和上皮厚度。28例患者接受圆锥角膜治疗。平均Kmax为56.18 ± 7.90。光学相干断层扫描（OCT）评估的最薄点为443.18 ± 39.75 μm。进行加速经上皮CXL，并在术后1周以及1、3、6和12个月记录矫正远视力（CDVA）、角膜地形图和OCT。所有眼睛的手术都很顺利。术后观察到上皮水肿，并在3天内消退。术后1周、1个月、3个月、6个月和12个月的Kmax分别为54.56 ± 8.81、55.78 ± 8.11、56.37 ± 8.71、55.80 ± 7.92和55.47 ± 8.24（均P > 0.05）。术后12个月观察到最薄角膜点，439.04 ± 44.99 μm（P = 0.109）。术后第1周上皮厚度下降，随后逐渐恢复。术后角膜厚度测量显示长达12个月无显著变化。术后上皮厚度暂时下降，然后在12个月稳定。加速的经上皮CXL被证明是治疗圆锥角膜的有效和安全的。
The thickness of corneal pachymetry and the epithelium after accelerated (45 mW/cm2) transepithelial corneal collagen cross-linking (CXL) for keratoconus were assessed in this prospective case series study. Twenty-eight patients were treated for keratoconus. The mean Kmax was 56.18 ± 7.90. The thinnest point, as assessed by optical coherence tomography (OCT), was 443.18 ± 39.75 μm. Accelerated transepithelial CXL was performed, and corrected distance visual acuity (CDVA), corneal topography, and OCT were recorded at 1 week postoperatively as well as at 1, 3, 6, and 12 months. The surgery was uneventful in all eyes. Postoperative epithelial edema was observed and faded in 3 days. The postoperative Kmax was 54.56 ± 8.81, 55.78 ± 8.11, 56.37 ± 8.71, 55.80 ± 7.92, and 55.47 ± 8.24 at 1 week, 1 month, 3 months, 6 months, and 12 months, respectively (all, P > 0.05). The thinnest postoperative corneal point, 439.04 ± 44.99 μm, was observed at 12 months (P = 0.109). The epithelial thickness decreased during the first postoperative week then showed a gradual recovery. Postoperative pachymetry thickness showed no significant changes for up to 12 months. Postoperative epithelial thickness decreased temporarily, then stabilized at month 12. Accelerated transepithelial CXL was shown to be effective and safe for the treatment of keratoconus.
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