Elements of regiocontrol in palladium-catalyzed oxidative arene cross-coupling
Elements of regiocontrol in palladium-catalyzed oxidative arene cross-coupling
复制标题
DOI：
10.1021/ja0745862
复制
发表时间：
2007-10-10
影响因子：
15
通讯作者：
Fagnou, Keith
中科院分区：
文献类型：
--
作者：
Stuart, David R.;Villemure, Elisia;Fagnou, Keith
在钯催化的氧化芳烃交叉偶联反应中，通过改变化学计量比的氧化剂和修饰吲哚N-取代基，可以高产率地实现C2和C3氧化吲哚芳基化反应。苯组分也可以达到很高的区域选择性，并说明了这种方法在吡咯底物上的使用。提出了C2/C3选择性变化的机理假说。
By changing the stoichiometric oxidant and modifying the indole N-substituent in palladium-catalyzed oxidative arene cross-coupling reactions, both C2 and C3 oxidative indole arylation can be achieved in high yield. High regioselectivity can also be achieved with the benzene component, and the use of this methodology with pyrrole substrates is illustrated. A mechanistic hypothesis for the change in C2/C3 selectivity is advanced.