Immunomodulatory effect of human umbilical cord Wharton's jelly-derived mesenchymal stem cells on lymphocytes.
Immunomodulatory effect of human umbilical cord Wharton's jelly-derived mesenchymal stem cells on lymphocytes.
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DOI：
10.1016/j.cellimm.2011.09.010
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发表时间：
2011
影响因子：
4.3
通讯作者：
Guan, Fangxia
中科院分区：
文献类型：
--
作者：
Zhou, Changhui;Yang, Bo;Tian, Yi;Jiao, Hongliang;Zheng, Wendi;Wang, Jian;Guan, Fangxia
关键词：
研究表明间充质干细胞（MSCs）具有低免疫原性和免疫调节能力。人脐带华氏冻为具有高增殖和多分化潜力的间充质干细胞提供了新的来源。为了研究人华氏水母细胞（WJCs）对淋巴细胞的免疫调节作用，我们成功地从人脐带华氏水母中分离出MSCs。wjc表达MSC标志物，但低水平人白细胞抗原(HLA)-ABC，无HLA- dr。这些结果表明wjc具有较低的免疫原性。WJCs及其培养上清液均能抑制植物血凝素刺激的人外周血淋巴细胞和小鼠脾细胞的增殖。此外，WJCs可抑制人外周血淋巴细胞分泌转化生长因子-β1和干扰素-γ。我们认为，WJCs的免疫调节作用可能与直接细胞接触和抑制人外周血淋巴细胞分泌细胞因子有关。
Studies have shown that mesenchymal stem cells (MSCs) have low immunogenicity and immune regulation. Human umbilical cord Wharton’s jelly provides a new source for MSCs that are highly proliferative and have multi-differentiation potential. To investigate immunomodulatory effects of human Wharton’s jelly cells (WJCs) on lymphocytes, we successfully isolated MSCs from human umbilical cord Wharton’s jelly. WJCs expressed MSC markers but low levels of human leukocyte antigen (HLA)-ABC and no HLA-DR. These results indicate that WJCs have low immunogenicity. Both WJCs and their culture supernatant could inhibit the proliferation of phytohemagglutinin-stimulated human peripheral blood lymphocytes and mouse splenocytes. Additionally, WJCs suppressed secretion of transforming growth factor-β1 and interferon-γ by human peripheral blood lymphocytes. We conclude that the immunomodulatory effect of WJCs may be related to direct cell contact and inhibition of cytokine secretion by human peripheral blood lymphocytes.
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影响因子：
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