Natural Endoperoxides as Drug Lead Compounds
Natural Endoperoxides as Drug Lead Compounds
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作为药物先导化合物的天然内过氧化物
DOI：
10.2174/0929867323666151127200949
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发表时间：
2016-01-01
影响因子：
4.1
通讯作者：
Hu, Liming
中科院分区：
文献类型：
--
作者：
Bu, Ming;Yang, Burton B.;Hu, Liming
天然产物，特别是作为药物先导化合物的生物活性分子，在促进健康和药物发现与开发方面受到了广泛的关注。在药物开发之前，了解这些先导分子的结构和作用机制是至关重要的。该综述提供了近年来文献中出现的130多种新报告的过氧化物质的综合信息。这些化合物是具有生物活性的天然过氧物。本文对大量新发现的具有最新信息的天然过氧物进行了综述，重点介绍了从陆地和海洋中分离得到的单萜、倍半萜、二萜、七萜类、三萜类和甾体过氧物等不同结构类别的生物活性。这些天然的过氧物是具有抗肿瘤和抗疟疾活性的药物发现的宝贵来源。
Natural products, especially bioactive molecules as drug lead compounds, have attracted extensive attention in health promotion and in drug discovery and development. It is essential to understand the structures and functional mechanisms of these lead molecules prior to drug development. This review provides comprehensive information for more than 130 newly reported peroxides appeared in the literature in the recent years. The compounds are natural peroxides with bioactivities. While some of them appeared in previous reviews, a great number of newly-found natural peroxides with up-dated information are extensively reviewed in this article, which focuses on the biological activities based on various structural classes including monoterpenoids, sesquiterpenoids, diterpenoids, sesterterpenoids, triterpenoids and steroidal peroxy compounds isolated from terrestrial and marine sources. These natural peroxides are valuable sources in drug discovery with antitumor and antimalarial activities.