Protective immunity to nematode infection is induced by CTLA-4 blockade.
Protective immunity to nematode infection is induced by CTLA-4 blockade.
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DOI：
10.1084/jem.186.2.183
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发表时间：
1997-07-21
期刊：
影响因子：
--
通讯作者：
Gros GL
中科院分区：
文献类型：
--
作者：
McCoy K;Camberis M;Gros GL
最近观察到T淋巴细胞受体CTLA-4的中和或基因缺失允许增强的T细胞反应性，这为针对感染因子的免疫疗法提供了新的机会。我们使用中和抗体阻断CTLA-4与其配体CD 80和CD 86在感染线虫巴西日本圆线虫的小鼠中的相互作用。CTLA-4阻断大大增强和加速了T细胞对N. brasiliensis，导致成虫数量大幅减少和寄生虫卵生产提前终止。CTLA-4阻断能够在急性感染期间将初级免疫反应加速至保护水平，这表明其作为应对传染性病原体的免疫治疗工具的潜力。
The recent observation that neutralization or genetic deletion of the T lymphocyte receptor CTLA-4 allows enhanced T cell reactivity offers new opportunities for immunotherapy against infectious agents. We used a neutralizing antibody to block CTLA-4 interaction with its ligands CD80 and CD86 during infection of mice with the nematode, Nippostrongylus brasiliensis. CTLA-4 blockade greatly enhanced and accelerated the T cell immune response to N. brasiliensis, resulting in a profound reduction in adult worm numbers and early termination of parasite egg production. The ability of CTLA-4 blockade to accelerate primary immune responses to a protective level during an acute infection indicates its potential as an immunotherapeutic tool for dealing with infectious agents.