Genetic and environmental sources of variation in heart rate response to infused nicotine in twins.
Genetic and environmental sources of variation in heart rate response to infused nicotine in twins.
复制标题
双胞胎心率对注射尼古丁反应变化的遗传和环境来源。
DOI：
10.1158/1055-9965.epi-06-1093
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Benowitz,NealL
中科院分区：
文献类型：
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作者：
Swan,GaryE;Lessov-Schlaggar,ChristinaN;Krasnow,RuthE;Wilhelmsen,KirkC;Jacob3rd,Peyton;Benowitz,NealL
心率对尼古丁的反应可能是导致依赖的过程中的一个重要组成部分。这项研究首次确定了遗传和环境来源在心率反应的各个组成部分中所起作用的程度。110对同卵双胞胎和29对异卵双胞胎接受了静脉注射。尼古丁和可替宁输注超过30分钟。在输液前、输液中和输液后30min，通过电子监护仪测量心率。测定尼古丁的清除量，作为尼古丁代谢率的指标。平均静息心率在输液前为64.7次/分(Bpm)，在输液结束时增加到平均72.7次/分。输注后30min，心率降至67.5次/分。在整个60分钟的测量中，年龄、当前吸烟状况、体重指数和尼古丁清除量与心率水平显著相关。在调整了几个协变量后，包括给药尼古丁剂量和尼古丁清除率，检查了心率反应曲线几个特征的差异，以确定遗传和环境来源的相对贡献。在总样本中，心率加速的变异高达30.3%是由加性遗传源引起的。在非吸烟者中，心率加速和减速的差异分别有34.8%和31.0%是由遗传因素造成的。心率加快和减速可能是中枢神经系统对尼古丁反应的反映。遗传来源对心率反应特征的贡献应进一步调查，作为尼古丁依赖遗传学研究的潜在内表型。(《癌症流行病学生物标记物》2007；16(6)：1057-)
The heart rate response to nicotine may be an important component of the process leading to dependence. The present study is the first to determine the extent to which genetic and environmental sources play a role in various components of the heart rate response. One hundred and ten monozygotic and 29 dizygotic twin pairs received an i.v. infusion of nicotine and cotinine over 30 min. Before, during, and for 30 min after infusion, heart rate was measured via an electronic monitor. The clearance of nicotine was determined as a measure of the rate of nicotine metabolism. Average resting heart rate before infusion was 64.7 beats per minutes (bpm), and at the termination of infusion, heart rate had increased to an average of 72.7 bpm. At 30 min after infusion, heart rate had decreased to 67.5 bpm. Age, current smoking status, body mass index, and nicotine clearance were associated significantly with heart rate levels over the full 60 min of measurement. After adjustment for several covariates, including dose of administered nicotine and rate of nicotine clearance, the variance in several characteristics of the heart rate response curve was examined for the relative contribution from genetic and environmental sources. In the total sample, as much as 30.3% of the variance in the acceleration of heart rate was due to additive genetic sources. In nonsmokers, 34.8% and 31.0% of variance in the acceleration and deceleration of heart rate, respectively, was due to genetic sources. Heart rate acceleration and deceleration may be a reflection of central nervous system responsiveness to nicotine. The contribution from genetic sources to heart rate response characteristics should be investigated further as a potential endophenotype for use in genetic studies of nicotine dependence. (Cancer Epidemiol Biomarkers Prev 2007;16(6):1057–64)