Structural and metabolic changes in the brain of patients with upper motor neuron disorders: A multiparametric MRI study
Structural and metabolic changes in the brain of patients with upper motor neuron disorders: A multiparametric MRI study
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DOI：
10.3109/17482960902777339
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Falini, Andrea
中科院分区：
文献类型：
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作者：
Charil, Arnaud;Corbo, Massimo;Falini, Andrea
我们的目的是评估和比较常规MRI（cMRI）、磁化传递成像（MTI）、弥散加权成像（DWI）和质子磁共振波谱成像（1H-MRSI）在肌萎缩侧索硬化（ALS）和原发性侧索硬化（PLS）患者中的诊断敏感性。38名ALS患者，9名PLS患者和22名健康对照者入组。行cMRI、MTI、DWI和H-1-MRSI检查。ALS患者分为晚期（Ap）-ALS（明确+很可能）和早期（Ep）-ALS（可能+很可能-实验室支持）。cMRI对Ap-ALS（63.4%）和PLS（71.9%）皮质脊髓束（CST）高信号的敏感性较高，而对Ep-ALS（17.1%）的敏感性较差。质子密度加权图像上的高信号与ALS严重程度相关（p = 0.02）。与对照组相比，ALS（p < 0.01）和PLS（p = 0.02）中CST表观扩散系数显著增加。与对照组相比，患者运动皮层的N-乙酰天冬氨酸/肌酸比值显著降低（p
Our objective was to assess and compare the diagnostic sensitivity of conventional MRI (cMRI), magnetization transfer imaging (MTI), diffusion-weighted imaging (DWI), and proton magnetic resonance spectroscopic imaging (1H-MRSI) in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS). Thirty-eight ALS patients, nine PLS patients, and 22 healthy controls were enrolled. cMRI, MTI, DWI and H-1-MRSI were obtained. ALS patients were classified as advanced phase (Ap)-ALS (definite + probable) and early phase (Ep)-ALS (possible + probable-laboratory supported). cMRI was highly sensitive in detecting corticospinal tract (CST) hyperintensities in Ap-ALS (63.4%) and PLS (71.9%), but it was poorly sensitive in Ep-ALS (17.1%). Hyperintensity on proton density-weighted images correlated with ALS severity (p = 0.02). CST apparent diffusion coefficient was significantly increased in ALS (p < 0.01) and PLS (p = 0.02) versus controls. The N-acetylaspartate/ creatine ratio was significantly reduced in the motor cortex of patients versus controls(p