Factors related to pregnancy and birth and the risk of childhood brain tumours: The ESTELLE and ESCALE studies (SFCE, France)
Factors related to pregnancy and birth and the risk of childhood brain tumours: The ESTELLE and ESCALE studies (SFCE, France)
复制标题
DOI：
10.1002/ijc.30597
复制
发表时间：
2017-04-01
影响因子：
6.4
通讯作者：
Clavel, Jacqueline
中科院分区：
文献类型：
--
作者：
Bailey, Helen D.;Rios, Paula;Clavel, Jacqueline
儿童脑瘤（CBT）的病因知之甚少。本研究的目的是调查极端出生体重是否与CBT风险增加有关，以及母亲孕前补充叶酸或母乳喂养是否会降低风险。此外，还调查了其他产妇特征和出生相关因素。我们汇集了2003-2004年和2010-2011年进行的两项基于人群的法国国家病例对照研究的数据。510例CBT患者的母亲（直接从国家儿童癌症登记处招募）和3102例年龄在15岁以下的对照，频率与年龄和性别相匹配，进行了电话采访，重点是人口统计学和围产期特征，以及母亲的生活方式习惯和生殖史。比值比（OR）和95%置信区间（CI）使用无条件逻辑回归进行估计，并根据年龄、性别、研究来源和相关混杂因素进行调整。CBT与出生体重或胎儿生长没有关联。孕前补充叶酸的情况很少（病例为5.3%，对照组为7.8%），OR为0.8 （95% CI 0.5, 1.4）。与母乳喂养，甚至更长时间（6个月或更长；or 1.0, 95% CI 0.8, 1.4）没有关联。CBT与其他调查因素（产妇体重指数、妊娠期体重增加、先天性异常、产妇生殖史或使用生育治疗）之间也没有任何关联。虽然这项研究规模很大，但对亚型分析的支持力度不足。将数据与其他基于人群的研究相结合，可以进一步了解CBT亚型的研究结果。
Little is known of the causes of childhood brain tumors (CBT). The aims of this study were to investigate whether extremes of birth weight were associated with increased risk of CBT and whether maternal preconceptional folic acid supplementation or breastfeeding reduced the risk. In addition, other maternal characteristics and birth related factors were also investigated. We pooled data from two French national population-based case-control studies with similar designs conducted in 2003-2004 and 2010-2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by age and gender did a telephone interview, which focussed on demographic and perinatal characteristics, and maternal life style habits and reproductive history. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusted for age, sex, study of origin and relevant confounders. No association was found between CBT and birth weight or fetal growth. The use of preconceptional folic acid supplementation was rare (5.3% in cases and 7.8% in controls) and the OR was 0.8 (95% CI 0.5, 1.4). There was no association with breastfeeding, even prolonged (six months or more; OR 1.0, 95% CI 0.8, 1.4). Neither was there any association between CBT and other investigated factors (maternal body mass index, gestational weight gain, congenital abnormality, maternal reproductive history or use of fertility treatments. Although large, this study was underpowered for subtype analyses. Pooling data with other population-based studies may provide further insight into findings by CBT subtypes.