TOLERANCE TO BACTERIAL PYROGENS : I. FACTORS INFLUENCING ITS DEVELOPMENT.
TOLERANCE TO BACTERIAL PYROGENS : I. FACTORS INFLUENCING ITS DEVELOPMENT.
复制标题
DOI：
10.1084/jem.86.1.29
复制
发表时间：
1947-06-30
期刊：
影响因子：
--
通讯作者：
Technical Assistance of Elizabeth Roberts
中科院分区：
文献类型：
--
作者：
Beeson PB;Technical Assistance of Elizabeth Roberts
在反复静脉注射伤寒沙门氏菌、粘质沙雷氏菌和铜绿假单胞菌致热物质对兔的发热反应的研究中，观察到以下几点：1.观察到每日注射相同剂量的致热物质的典型反应模式。这包括在第一周或10天内发热反应的逐渐减少，在此之后，即使继续注射几周，动物对每次注射也会有大致相同程度的发热反应。2.每半周或每周注射等量致热物质的动物，发热反应有所减轻，但变化不如每天注射的动物明显。3.热原耐受性丧失的速度较快。被允许休息约3周的动物对再次注射热原的反应与第一次注射后的发烧情况相当。4.通过逐渐增加热原每日剂量的大小，可以建立耐受性，从而减少但仍然相当大的量的热原不会引起任何发烧。5.注射粘质链霉菌或粘质链球菌的兔。铜绿假单胞菌热原对伤寒沙门氏菌疫苗的发热反应减弱。6.不能表现出对热原的无反应性被动转移。7.在免疫过程中使用退热药防止体温升高并不干扰对热原的耐受性的形成。8.一系列机械引起的发烧并未降低对细菌热原的反应性。
In a study of the febrile responses of rabbits to repeated intravenous injections of pyrogenic substances from Eberthella typhosa, Serratia marcescens, and Pseudomonas aeruginosa, the following observations were made: 1. A characteristic pattern of response to daily injections of the same dose of pyrogenic material was noted. This consisted of a progressive diminution in febrile response during the 1st week or 10 days, after which an animal responded to each injection with approximately the same degree of fever, even when the injections were continued for several weeks. 2. Animals given injections of the same amount of pyrogenic material at semiweekly or weekly intervals showed some diminution in febrile reaction but the alteration was less pronounced than that in animals injected every day. 3. Pyrogen tolerance appeared to be lost quickly. Animals allowed to rest for approximately 3 weeks reacted to readministration of pyrogen with fever comparable with that which occurred after the first injection. 4. By gradually increasing the size of the daily dose of pyrogen a tolerance could be established such that a reduced, but still considerable, amount of pyrogen caused no fever whatever. 5. Rabbits that had been injected with S. marcescens or Ps. aeruginosa pyrogens showed a diminished febrile response to E. typhosa vaccine. 6. Passive transfer of the unresponsiveness to pyrogens could not be demonstrated. 7. Prevention of temperature elevations during the course of immunization by use of an antipyretic drug did not interfere with the development of tolerance to pyrogens. 8. A series of mechanically induced bouts of fever did not reduce the responsiveness to bacterial pyrogens.