Cloning and sequencing of a leech homolog to the Drosophila engrailed gene.
Cloning and sequencing of a leech homolog to the Drosophila engrailed gene.
复制标题
果蝇 engrailed 基因的水蛭同源物的克隆和测序。
DOI：
10.1016/0014-5793(91)80172-y
复制
发表时间：
1991
期刊：
影响因子：
3.5
通讯作者：
Weisblat,DA
中科院分区：
文献类型：
--
作者：
Wedeen,CJ;Price,DJ;Weisblat,DA
We have cloned and sequenced a homolog (ht‐en) to theDrosphilaengrailed (en) gene from the glossiphoniid leech,Helobdella triserialis. Amino acid comparisons of the ht‐en homeodomain andC‐terminal residues with the corresponding residues encoded byen‐class genes of other species reveal 75–79% sequence identity. In addition, the ht‐en sequence appears to have u serine‐rich region 16 residuesC‐terminal from the homeodomain, which by analogy toDrosophilamay be a target site for phosphorylation. The leech gene encodes some amino acid substitutions for residues that are highly conserved in other species. These are found within the second and third of the three putative helices of the homeodomain, and in both of the intervening turn regions.
