Cross-cultural assessment of HIV-associated cognitive impairment using the Kaufman assessment battery for children: a systematic review.
Cross-cultural assessment of HIV-associated cognitive impairment using the Kaufman assessment battery for children: a systematic review.
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使用Kaufman评估电池对与HIV相关的认知障碍进行跨文化评估：系统评价。
DOI：
10.7448/ias.20.1.21412
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发表时间：
2017-06-14
影响因子：
6
通讯作者：
Thomas KG
中科院分区：
文献类型：
--
作者：
van Wyhe KS;van de Water T;Boivin MJ;Cotton MF;Thomas KG
导读：尽管抗逆转录病毒联合治疗（cART）的疗效和可及性有所提高，但艾滋病毒相关的认知障碍在儿童和成人中仍然普遍存在。检测这种损伤的神经心理学测试可以帮助临床医生制定有效的治疗计划。Kaufman Assessment Battery for Children （KABC）虽然是在美国开发和标准化的，但在许多不同的国家和文化背景下经常被用来评估儿童在不同认知领域的表现。本系统综述调查了最初的KABC及其第二版（KABC- ii）在检测儿童和青少年hiv相关认知障碍方面的跨文化效用。方法：在PubMed、PsycInfo、EBSCOHost、ProQuest和Scopus数据库中输入相关关键词和MeSH术语，检索范围为1983-2017年。两名独立审稿人对检索到的摘要和手稿进行了评估。有资格纳入本综述的研究包括：(a)使用KABC/KABC- ii来评估2 - 18岁儿童/青少年的认知功能，(b)具有认知障碍的定义（例如>.2 SD低于平均值）或比较艾滋病毒感染者和未感染对照组的表现，以及(c)使用的样本排除在工具规范的人群之外。结果和讨论：我们确定了9项研究（8项在非洲国家进行，1项在英国进行）来组成综述的样本。所有研究都发现感染艾滋病毒的儿童存在认知障碍，包括cART-naïve或接受cART治疗且临床稳定的儿童。评估同时加工的KABC/KABC- ii子测试最为敏感。两篇独立综述对所选研究的方法学质量进行了评估，表明缺点包括报告和选择偏差。结论：本系统综述为KABC/KABC- ii在检测hiv感染儿童（包括临床稳定的儿童）的认知障碍方面的跨文化效用提供了证据，特别是同时处理子测试。虽然目前的结果表明，主要在东非使用KABC/KABC- ii是合理的，但需要进一步调查以探索该仪器在全球其他艾滋病毒流行地区的效用。
Introduction: Despite improved efficacy of, and access to, combination antiretroviral therapy (cART), HIV-associated cognitive impairments remain prevalent in both children and adults. Neuropsychological tests that detect such impairment can help clinicians formulate effective treatment plans. The Kaufman Assessment Battery for Children (KABC), although developed and standardized in the United States, is used frequently in many different countries and cultural contexts to assess paediatric performance across various cognitive domains. This systematic review investigated the cross-cultural utility of the original KABC, and its 2nd edition (KABC-II), in detecting HIV-associated cognitive impairment in children and adolescents. Methods: We entered relevant keywords and MeSH terms into the PubMed, PsycInfo, EBSCOHost, ProQuest, and Scopus databases, with search limits set from 1983–2017. Two independent reviewers evaluated the retrieved abstracts and manuscripts. Studies eligible for inclusion in the review were those that (a) used the KABC/KABC-II to assess cognitive function in children/adolescents aged 2–18 years, (b) featured a definition of cognitive impairment (e.g. >2 SD below the mean) or compared the performance of HIV-infected and uninfected control groups, and (c) used a sample excluded from population on which the instruments were normed. Results and discussion: We identified nine studies (eight conducted in African countries, and one in the United Kingdom) to comprise the review’s sample. All studies detected cognitive impairment in HIV-infected children, including those who were cART-naïve or who were cART treated and clinically stable. KABC/KABC-II subtests assessing simultaneous processing appeared most sensitive. Evaluation of the methodological quality of the selected studies by two independent reviews suggested that shortcomings included reporting and selection biases. Conclusions: This systematic review provides evidence for the cross-cultural utility of the KABC/KABC-II, particularly the simultaneous processing subtests, in detecting cognitive impairment in HIV-infected children (including those who are clinically stable). Although the current results suggest there is justification for using the KABC/KABC-II primarily in East Africa, further investigation is required to explore the instrument’s utility in other HIV-prevalent regions of the globe.