RELATION OF FETAL AND INFANT GROWTH TO PLASMA-FIBRINOGEN AND FACTOR-VII CONCENTRATIONS IN ADULT LIFE
RELATION OF FETAL AND INFANT GROWTH TO PLASMA-FIBRINOGEN AND FACTOR-VII CONCENTRATIONS IN ADULT LIFE
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DOI：
10.1136/bmj.304.6820.148
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发表时间：
1992-01-18
影响因子：
105.7
通讯作者：
STIRLING, Y
中科院分区：
文献类型：
--
作者：
BARKER, DJP;MEADE, TW;STIRLING, Y
目的-为了确定是否减少胎儿和婴儿的生长与较高的血浆纤维蛋白原和因子VII浓度在adultlifes.Design -随访研究的男性在1920年至30年期间出生的体重在出生时，并在1年已记录的健康访视，和男性在1935年至43年期间出生的大小在出生时已详细测量。研究对象：591名出生在赫特福德郡东部的男性，他们仍然住在赫特福德郡东部，148名出生在普雷斯顿的男性，他们仍然住在该市或附近。主要结果指标：血浆纤维蛋白原和因子VII浓度。结果：赫特福德郡男性的平均血浆纤维蛋白原和因子VII浓度在1年后随着体重的增加而下降（从小于或等于18磅的男性的3.21克/升到大于或等于27磅的男性的2-93克/升，从标准的122%到103%; p < 0.001，p < 0.005）。这些趋势与吸烟、饮酒、体重指数和社会阶层无关。无论是血浆纤维蛋白原，也没有因子VII浓度与出生体重。然而，在普雷斯顿的男性中，纤维蛋白原浓度随着胎盘重量与出生体重之比的降低而逐渐下降（p = 0.01）。结论-胎儿和婴儿期生长减少与止血因子纤维蛋白原和因子VII的高血浆浓度密切相关。这可能是在关键的早期阶段对肝脏发育受损的持续反应。
Objective - To determine whether reduced fetal and infant growth are associated with higher plasma fibrinogen and factor VII concentrations in adult life.Design - Follow up study of men born during 1920-30 whose weights at birth and at 1 year had been recorded by health visitors, and men born during 1935-43 whose size at birth had been measured in detail.Setting - Hertfordshire and Preston, England.Subjects - 591 men born in east Hertfordshire who still lived there and 148 men born in Preston who still lived in or close to the city.Main outcome measures - Plasma fibrinogen and factor VII concentrations.Results - Among men in Hertfordshire mean plasma fibrinogen and factor VII concentrations fell with increasing weight at 1 year (from 3.21 g/l in men of less-than-or-equal-to 18 lb to 2-93 g/l in men of greater-than-or-equal-to 27 lb and from 122% of standard to 103%; p < 0.001, p < 0.005 respectively). The trends were independent of cigarette smoking, alcohol consumption, body mass index, and social class. Neither plasma fibrinogen nor factor VII concentration was related to birth weight. In men in Preston, however, fibrinogen concentration fell progressively as the ratio of placental weight to birth weight decreased (p = 0.01).Conclusions - Reduced growth in fetal life and infancy is strongly related to high plasma concentrations of the haemostatic factors fibrinogen and factor VII. This may be a persisting response to impaired liver development during a critical early period.