The ER/PM microdomain, PI(4,5)P₂ and the regulation of STIM1-Orai1 channel function.
The ER/PM microdomain, PI(4,5)P₂ and the regulation of STIM1-Orai1 channel function.
复制标题
DOI：
10.1016/j.ceca.2015.03.003
复制
发表时间：
2015-10
期刊：
影响因子：
4
通讯作者：
Muallem S
中科院分区：
文献类型：
--
作者：
Cao X;Choi S;Maléth JJ;Park S;Ahuja M;Muallem S
所有形式的细胞信号传导都发生在离散的细胞微域中，其中ER是主要参与者，并且包括由ER与溶酶体、内体、细胞核、线粒体和质膜形成的微域。在微区中，两个相对的细胞器转移和交换包括脂质和离子在内的成分。与其他形式的信号传导途径一样，受体诱发的Ca 2+信号的许多组分聚集在ER/PM微区，包括Orai 1-STIM 1复合物。这篇综述讨论了最近的进展，了解拴系ER和质膜，形成ER/PM微域中PI（4，5）P2是丰富的分子组成部分，以及如何动态靶向Orai 1-STIM 1复合物PI（4，5）P2-穷人和PI（4，5）P2-丰富的微域控制Orai 1的活性和它的调节由Ca 2+介导的SARAF。
All forms of cell signaling occur in discreet cellular microdomains in which the ER is the main participant and include microdomains formed by the ER with lysosomes, endosomes, the nucleus, mitochondria and the plasma membrane. In the microdomains the two opposing organelles transfer and exchange constituents including lipids and ions. As is the case for other forms of signaling pathways, many components of the receptor-evoked Ca2+ signal are clustered at the ER/PM microdomain, including the Orai1-STIM1 complex. This review discusses recent advances in understanding the molecular components that tether the ER and plasma membrane to form the ER/PM microdomains in which PI(4,5)P2 is enriched, and how dynamic targeting of the Orai1-STIM1 complex to PI(4,5)P2-poor and PI(4,5)P2-rich microdomains controls the activity of Orai1 and its regulation by Ca2+ that is mediated by SARAF.