LESS MORTALITY BUT MORE RELAPSES IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN CD8-/- MICE
LESS MORTALITY BUT MORE RELAPSES IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN CD8-/- MICE
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DOI：
10.1126/science.256.5060.1210
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发表时间：
1992-05-22
期刊：
影响因子：
56.9
通讯作者：
MAK, TW
中科院分区：
文献类型：
--
作者：
KOH, DR;FUNGLEUNG, WP;MAK, TW
缺乏 CD8 的小鼠是通过胚胎干细胞中 CD8 位点的同源重组产生的，并与实验性过敏性脑脊髓炎 (EAE) 易感的 PL/J H-2u 进行四次回交繁殖，以研究 CD8+ T 细胞在多发性硬化症模型中的作用。发病和易感性与野生型小鼠相似。然而，突变小鼠的急性 EAE 较轻，表现为死亡较少，但慢性 EAE 较多，表现为复发频率较高。这表明 CD8+ T 淋巴细胞可能作为该动物模型中的效应器和调节器参与。
Mice lacking in CD8 were generated from homologous recombination in embryonal stem cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)-susceptible PL/J H-2u through four backcross generations to investigate the role of CD8+ T cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This suggests that CD8+ T lymphocytes may participate as both effectors and regulators in this animal model.