The incidence of ulcerative colitis (1995-2011) and Crohn's disease (1995-2012) - Based on nationwide Danish registry data
The incidence of ulcerative colitis (1995-2011) and Crohn's disease (1995-2012) - Based on nationwide Danish registry data
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DOI：
10.1016/j.crohns.2014.03.006
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发表时间：
2014-10-01
影响因子：
8
通讯作者：
Qvist, Niels
中科院分区：
文献类型：
--
作者：
Norgard, Bente Mertz;Nielsen, Jan;Qvist, Niels
背景和目标：溃疡性结肠炎（UC）和克罗恩病（CD）的发病率在世纪在北美和西欧增加。然而，关于发病率是否已经下降、稳定或甚至继续增加的报告相互矛盾。1992年后，丹麦全国范围内没有关于UC和CD发病率的数据，因此我们研究了UC（1995年至2011年）和CD（1995年至2012年）的发病率。方法：根据丹麦国家患者登记处的数据，我们确定了研究期间首次诊断为UC或CD的患者。在这些患者中，只有纳入研究的事件的情况下，如果他们有至少一个以上的UC/CD或至少三个后续门诊vision.Results：我们确定了17,500例UC和7863例CD患者出院诊断。1995-1998年，UC的平均发病率为女性14.4/100，000/年，男性13.8/100，000/年，2009-2011年期间，女性和男性分别增至23.2/100，000/年和23.4/100，000/年。1995-1998年CD的平均发病率为女性每年每10万人7.8例，男性每年每10万人5.6例，2009- 2012年期间女性每年每10万人10.3例，男性每年每10万人8.9例。根据过去二十年丹麦全国范围的数据，UC和CD的发病率持续增加。(C)2014年欧洲克罗恩病和结肠炎组织。Elsevier B. V.出版，保留所有权利。
Background and aims: The incidence of ulcerative colitis (UC) and Crohn's disease (CD) has increased during the 20th century in North America and Western Europe. However, there are conflicting reports whether the incidence has declined, stabilized or even continued to increase. No nationwide Danish data on the incidence of UC and CD exist after 1992, and therefore we studied the incidence of UC (1995 through 2011) and CD (1995 through 2012).Methods: Based on data from the Danish National Patient Registry we identified patients recorded with a first time diagnosis of UC or CD in the study periods. Among these patients were only included in the study as incident cases if they had at least one more discharge diagnosis of UC/CD or at least three subsequent outpatient visits.Results: We identified 17,500 patients with UC and 7863 patients with CD. The mean incidence rate for UC in 1995-1998 was 14.4 per 100,000 per year for women and 13.8 for men, increasing to 23.2 per 100,000 per year for women and 23.4 for men in the period of 2009-2011. The mean incidence rate for CD in 1995-1998 was 7.8 per 100,000 per year for women and 5.6 for men, increasing to 10.3 per 100,000 per year for women and 8.9 for men in the period of 2009-2012.Conclusions: Based on nationwide Danish data from the last two decades, the incidence rates of UC and CD have continued to increase. (C) 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.