Body composition at age 9 years, maternal folate intake during pregnancy and methyltetrahydrofolate reductase (MTHFR) C677T genotype
Body composition at age 9 years, maternal folate intake during pregnancy and methyltetrahydrofolate reductase (MTHFR) C677T genotype
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DOI：
10.1017/s0007114509231746
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发表时间：
2009-08-28
影响因子：
3.6
通讯作者：
Ness, Andy
中科院分区：
文献类型：
--
作者：
Lewis, Sarah J.;Leary, Sam;Ness, Andy
怀孕期间和生命早期的营养可能会影响发育可塑性，并改变对肥胖和成人疾病的易感性。发生这种情况的一种机制是通过表观遗传变化，如甲基化水平的变化，这会改变基因表达模式。叶酸摄入量在怀孕期间，以及母亲的甲基四氢叶酸还原酶（MTHFR）C677T基因型，影响甲基供体的甲基化在怀孕期间的可用性，因此可能与后代的身体组成在儿童期。我们研究了来自英国一项基于人群的出生队列研究的5783名儿童在怀孕18周和32周时母亲补充叶酸、怀孕32周时饮食中叶酸摄入量（来自自我报告的FFQ）与9岁时后代身体组成之间的关系。我们还研究了母亲和后代的MTHFR C677T基因型与后代身体组成的关系。我们没有发现证据支持子宫内暴露于叶酸会影响儿童身体组成的假设。
Nutrition during pregnancy and in early life may influence developmental plasticity and alter susceptibility to obesity and adult disease. One mechanism by which this could occur is through epigenetic changes, such as changes in methylation levels, which modify gene expression patterns. Folate intake during pregnancy, as well as maternal methyltetrahydrofolate reductase (MTHFR) C677T genotype, influences the availability of methyl donors for methylation during gestation and therefore may be associated with offspring body composition in childhood. We looked at associations between maternal folic acid supplementation at 18 and 32 weeks of pregnancy, folate intake in the diet (from self-reported FFQ) at 32 weeks of pregnancy and offspring body composition at age 9 years among 5783 children from a population-based birth cohort study in the UK. We also looked at maternal and offspring's MTHFR C677T genotype in relation to offspring body composition. We found no evidence to Support the hypothesis that intra-uterine exposure to folate influences childhood body composition.