The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism.
The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism.
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DOI：
10.3389/fendo.2023.1217875
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
肥胖和2型糖尿病是影响数千万至数亿成年人的慢性代谢疾病，特别是在发达国家。每种情况都与乳腺癌的风险升高和治疗后的预后不良有关。将代谢健康状况差与乳腺癌联系起来的机制有很多，包括高胰岛素血症、炎症、过量营养供应和脂肪组织功能障碍。在这里，我们专注于脂肪组织，突出脂肪细胞和成纤维细胞在乳腺癌进展中的重要作用。脂肪组织对乳腺癌影响的一个潜在重要介质是成纤维细胞生长因子受体（FGFR）信号网络。在FGFR信号传导的许多作用中，我们假设驱动侵袭性乳腺癌的关键机制包括上皮向间质转化和细胞代谢重编程。我们还提出了一些现有的问题，这些问题可能有助于更好地了解肥胖、2型糖尿病和代谢健康不良人群的乳腺癌生物学。
Obesity and type 2 diabetes are chronic metabolic diseases that impact tens to hundreds of millions of adults, especially in developed countries. Each condition is associated with an elevated risk of breast cancer and with a poor prognosis after treatment. The mechanisms connecting poor metabolic health to breast cancer are numerous and include hyperinsulinemia, inflammation, excess nutrient availability, and adipose tissue dysfunction. Here, we focus on adipose tissue, highlighting important roles for both adipocytes and fibroblasts in breast cancer progression. One potentially important mediator of adipose tissue effects on breast cancer is the fibroblast growth factor receptor (FGFR) signaling network. Among the many roles of FGFR signaling, we postulate that key mechanisms driving aggressive breast cancer include epithelial-to-mesenchymal transition and cellular metabolic reprogramming. We also pose existing questions that may help better understand breast cancer biology in people with obesity, type 2 diabetes, and poor metabolic health.
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影响因子：
6
作者：
Holowatyj AN;Gigic B;Warby CA;Ose J;Lin T;Schrotz-King P;Ulrich CM;Bernard JJ
通讯作者：
Bernard JJ
影响因子：
3.3
作者：
Benham, Vanessa;Chakraborty, Debrup;Bernard, Jamie J.
通讯作者：
Bernard, Jamie J.
影响因子：
--
作者：
Brown WS;Akhand SS;Wendt MK
通讯作者：
Wendt MK
影响因子：
13.6
作者：
Bonet, Catalina;Crous-Bou, Marta;Tsilidis, Konstantinos K.;Gunter., Marc J.;Kaaks., Rudolf;Schulze, Matthias. B.;Fortner, Renee T.;Antoniussen, Christian S.;Dahm, Christina C.;Mellemkjaer, Lene;Tjonneland, Anne;Amiano, Pilar;Ardanaz, Eva;Colorado-Yohar, Sandra M.;Rodriguez-Barranco, Miguel;Tin, Sandar Tin;Agnoli, Claudia;Masala, Giovanna;Panico, Salvatore;Sacerdote, Carlotta;May, Anne M.;Borch, Kristin Benjaminsen;Rylander, Charlotta;Skeie, Guri;Christakoudi, Sofia;Aune, Dagfinn;Weiderpass, Elisabete;Dossus, Laure;Riboli, Elio;Agudo, Antonio
通讯作者：
Agudo, Antonio
转录因子NFIB和YBX1的ERα结合使FGFR2信号传导能够调节乳腺癌中的雌激素反应性。
影响因子：
11.2
作者：
Campbell TM;Castro MAA;de Oliveira KG;Ponder BAJ;Meyer KB
通讯作者：
Meyer KB