A molecular Swiss army knife: OmpA structure, function and expression
A molecular Swiss army knife: OmpA structure, function and expression
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DOI：
10.1111/j.1574-6968.2007.00778.x
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发表时间：
2007-08-01
影响因子：
2.1
通讯作者：
Fagan, Robert P.
中科院分区：
文献类型：
--
作者：
Smith, Stephen G. J.;Mahon, Vivienne;Fagan, Robert P.
大肠杆菌和其他肠细菌的OmpA外膜蛋白是一种多面蛋白。这种蛋白质表达水平非常高，ompA在转录后水平受到严格调控。它可以作为粘附素和侵袭素，参与生物膜形成，作为免疫靶标和evasin，并作为几种噬菌体的受体。这些特性中的许多是由于从蛋白质散发到细胞外部的四个短蛋白质环。本文描述了这种蛋白质的结构如何与其许多功能相关。
The OmpA outer membrane protein of Escherichia coli and other enterobacteria is a multifaceted protein. This protein is expressed to very high levels and ompA is tightly regulated at the posttranscriptional level. It can function as an adhesin and invasin, participate in biofilm formation, act as both an immune target and evasin, and serves as a receptor for several bacteriophages. Many of these properties are due to four short protein loops that emanate from the protein to the outside of the cell. Herein it is described how the structure of this protein relates to its many functions.