AN EXPERIMENTAL-MODEL OF ACUTE AND SUBACUTE VIRAL MYOCARDITIS IN THE PIG
AN EXPERIMENTAL-MODEL OF ACUTE AND SUBACUTE VIRAL MYOCARDITIS IN THE PIG
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DOI：
10.1016/0735-1097(92)90533-s
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发表时间：
1992-03-15
影响因子：
24
通讯作者：
ABELMANN, WH
中科院分区：
文献类型：
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作者：
GWATHMEY, JK;NAKAO, S;ABELMANN, WH
用脑心肌炎病毒感染26头仔猪，经临床观察、无创性和有创性心功能检查和病理检查，发现所有感染动物均出现食欲减退、嗜睡和发热等症状。 感染后1 ~ 4天或20 ~ 21天发生自发性死亡。 在大多数动物中观察到的心电图异常包括ST-T波改变、传导障碍或室性异位心律。 大多数动物表现出左心室扩张和收缩功能下降的超声心动图证据，随着时间的推移，改善在一些animal.Hemodynamic研究显示，在10只动物的双心室充盈压升高，作为一个组，感染的动物表现出显着升高的右心室充盈压。 在选定的动物中，镓扫描以及左心室造影和冠状动脉造影术的可行性得到了证明。在尸检时，心脏重量/体重比显着升高，在感染的动物。 除两只动物外，所有动物的心脏均表现出活动性心肌炎，并在后期出现纤维化和局灶性钙化。总体而言，心血管表现与人类急性和亚急性心肌炎相似。 可以得出结论，猪脑心肌炎感染是一个大型的病毒性心肌炎动物模型，适合于评估心血管系统的结构和功能的改变和干预措施的效果。
Twenty-six young pigs were infected with encephalomyocarditis virus, observed clinically, studied at intervals by noninvasive and invasive methods to assess cardiac function and eventually examined pathologically.All infected animals appeared ill, usually manifesting diminished appetite, lethargy and fever. Spontaneous mortality occurred either 1 to 4 or 20 to 21 days after infection. Electrocardiographic abnormalities, seen in the majority of animals, comprised ST-T wave changes, conduction disturbances or ventricular ectopic rhythm. The majority of animals manifested echocardiographic evidence of left ventricular dilation and decreased systolic function, which improved with time in some animals.Hemodynamic studies revealed elevation of biventricular filling pressures in 3 of 10 animals; as a group, infected animals manifested significantly elevated right ventricular filling pressures. In selected animals, the feasibility of gallium scans as well as left ventriculography and coronary angiography was demonstrated.At autopsy, heart weight/body weight ratio was significantly elevated in infected animals. The heart of all but two animals showed active myocarditis associated with fibrosis and focal calcification in the later stages.In general, the cardiovascular manifestations were parallel with those seen in acute and subacute myocarditis in humans. It is concluded that encephalomyocarditis infection in the pig is a large animal model of viral myocarditis suitable for assessing alterations in the structure and function of the cardiovascular system and the effects of interventions.