Differential elasticity of the immature retina: a contribution to the development of the area centralis?
Differential elasticity of the immature retina: a contribution to the development of the area centralis?
复制标题
未成熟视网膜的弹性差异：对中央区域发育的贡献？
DOI：
10.1017/s0952523800011974
复制
发表时间：
1989
影响因子：
1.9
通讯作者：
Finlay,BL
中科院分区：
文献类型：
--
作者：
Kelling,ST;Sengelaub,DR;Wikler,KC;Finlay,BL
具有初始均匀细胞密度的视网膜表面的差异拉伸已被反复暗示为在成人视网膜中产生细胞密度的地形组织的发育机制之一，特别是中心区或视觉条纹与周边区域。众所周知，在发育过程中，需要眼内压来产生视网膜的正常构象和变薄。我们测试了视网膜具有弹性的可能性，这种弹性可能允许与眼内压相关的差异拉伸。在7 - 12日龄猫中，将包含推定的中央区的视网膜的相对变形与等效施加流体位移的周边视网膜的变形进行比较。周边视网膜变形显着更多，与假设的差异，在当地的弹性发展中的神经视网膜有助于其特征地形变化。因此，生长中的眼睛的生物力学特性可能有助于对视觉阵列的图案进行采样的机制。
Differential stretch of a retinal surface with an initially uniform cell density has been repeatedly implicated as one of the developmental mechanisms that produces the topographic organization of cell density in the adult retina, notably the area centralis or visual streak versus peripheral regions. It is known that intraocular pressure is required to produce the normal conformation and thinning of the retina during development. We tested the possibility that the retina has elastic properties that might permit differential stretch in conjunction with intraocular pressure. The relative deformation of the retina containing the presumptive area centralis was compared to the deformation of peripheral retina at equivalent applied fluid displacements in 7–12-day-old cats. The peripheral retina deformed significantly more, consistent with the hypothesis that differences in the local elasticities of the developing neural retina contribute to its characteristic topographic changes. Thus, a biomechanical property of the growing eye may contribute to the mechanism by which the pattern of the visual array is sampled.