Chinese herbal medicine Qing-Dai-induced pulmonary arterial hypertension in a patient with ulcerative colitis: A case report and experimental investigation
Chinese herbal medicine Qing-Dai-induced pulmonary arterial hypertension in a patient with ulcerative colitis: A case report and experimental investigation
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DOI：
10.1016/j.rmcr.2019.02.007
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发表时间：
2019-01-01
影响因子：
1.1
通讯作者：
Nishimura, Masaharu
中科院分区：
文献类型：
--
作者：
Sato, Kazuki;Ohira, Hiroshi;Nishimura, Masaharu
最近的一份病例报告描述了一例与使用中草药青黛相关的肺动脉高压（PAH）病例;然而，尚未描述其临床病程和可能的机制。我们提出的情况下，溃疡性结肠炎的男子谁被诊断为特发性肺动脉高压。在开始口服贝前列素治疗后，患者表现出显著的血流动力学改善和不寻常的临床恢复过程。2016年，日本厚生劳动省发布了关于清黛可能的副作用的警告。我们了解到我们的病人已经服用了2年的自购清黛。因此，我们进行了一项实验研究，并确定清黛可能通过一氧化氮合酶抑制和肺动脉内皮功能障碍的机制引起PAH。
A recent case report described a case of pulmonary arterial hypertension (PAH) associated with use of the Chinese herbal medicine Qing-Dai; however, the clinical course and possible mechanisms have not been characterized. We present the case of a man with ulcerative colitis who was diagnosed with idiopathic PAH. After initiating oral beraprost therapy, the patient showed significant hemodynamic improvements and an unusual course of clinical recovery. In 2016, the Japanese Ministry of Health, Labour, and Welfare issued a warning regarding the possible side effects of Qing-Dai. We learned that our patient had been taking self-purchased Qing-Dai for 2 years. Therefore, we performed an experimental study and determined that Qing-Dai may cause PAH through a mechanism involving nitric oxide synthase inhibition and pulmonary artery endothelial dysfunction.