Impaired mentalizing in depression and the effects of borderline personality disorder on this relationship.
Impaired mentalizing in depression and the effects of borderline personality disorder on this relationship.
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DOI：
10.1186/s40479-021-00153-x
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发表时间：
2021-05-04
影响因子：
4.1
通讯作者：
Montague RP
中科院分区：
文献类型：
--
作者：
Rifkin-Zybutz RP;Moran P;Nolte T;Feigenbaum J;King-Casas B;London Personality and Mood Disorder Consortium;Fonagy P;Montague RP
心理化，理解自我和他人的能力，以及在有意的精神状态方面的行为，在边缘型人格障碍（BPD）中受损。在其他精神障碍（如抑郁症）中，心理化缺陷的证据不太可靠，在解释BPD对心理化的影响时，这些联系从未被探索过。此外，目前还不清楚BPD症状是否可能缓和抑郁症状和心理化之间的任何关系。使用多变量回归模型的横截面数据从一个样本的274名参与者从临床环境中招募，我们调查了心理障碍和抑郁症之间的关联，并检查这是否是缓和的存在和并发BPD症状的数量，同时调整社会人口学混杂因素。在调整社会人口学混杂因素和BPD症状后，心智受损与抑郁症状相关（p = 0.002，β =-0.18）。BPD症状显着缓和受损的心理化和抑郁症状之间的关联（p = 0.003），更严重的边缘症状与心理化不良对抑郁症状增加的影响更强。即使在调整了BPD症状的影响后，抑郁症也会出现心智障碍。我们的研究结果有助于进一步证实抑郁症的损害，以及BPD症状对这种关联的调节作用。需要进一步的纵向工作来调查关联的方向。在线版本包含补充材料，可通过10.1186/s40479-021-00153-x获得。
Mentalizing, the ability to understand the self and others as well as behaviour in terms of intentional mental states, is impaired in Borderline Personality Disorder (BPD). Evidence for mentalizing deficits in other mental disorders, such as depression, is less robust and these links have never been explored while accounting for the effects of BPD on mentalizing. Additionally, it is unknown whether BPD symptoms might moderate any relationship between depressive symptoms and mentalizing. Using multivariate regression modelling on cross-sectional data obtained from a sample of 274 participants recruited from clinical settings, we investigated the association between mentalizing impairment and depression and examined whether this was moderated by the presence and number of concurrent BPD symptoms, while adjusting for socio-demographic confounders. Impaired mentalizing was associated with depressive symptoms, after adjustment for socio-demographic confounders and BPD symptoms (p = 0.002, β = − 0.18). BPD symptoms significantly moderated the association between impaired mentalizing and depressive symptoms (p = 0.003), with more severe borderline symptoms associated with a stronger effect of poor mentalization on increased depressive symptoms. Mentalizing impairments occur in depression even after adjusting for the effect of BPD symptoms. Our findings help further characterise mentalizing impairments in depression, as well as the moderating effect of BPD symptoms on this association.. Further longitudinal work is required to investigate the direction of association. The online version contains supplementary material available at 10.1186/s40479-021-00153-x.
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DOI：
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发表时间：
2008-01-01
影响因子：
0.9
作者：
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发表时间：
2011-03-01
影响因子：
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作者：
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通讯作者：
Staun, Lenka
影响因子：
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作者：
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