Activation of erythropoietin signaling by receptor dimerization.
Activation of erythropoietin signaling by receptor dimerization.
复制标题
通过受体二聚化激活促红细胞生成素信号传导。
DOI：
10.1016/s1357-2725(99)00075-8
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Watowich,SS
中科院分区：
文献类型：
--
作者：
Watowich,SS
促红细胞生成素（Epo）是红细胞发育所必需的激素。促红细胞生成素结合红系祖细胞表面的高亲和力受体，刺激受体二聚化和激活支持红系细胞存活、增殖和分化的细胞内信号转导途径。对促红细胞生成素受体（EpoR）的生化和结构分析揭示了EpoR功能的分子机制，为小分子Epo模拟物的开发开辟了道路。本文综述了EpoR二聚化在受体功能中的作用。
The hormone erythropoietin (Epo) is essential for red blood cell development. Epo binds a high affinity receptor on the surface of erythroid progenitor cells, stimulating receptor dimerization and activation of the intracellular signal transduction pathways that support erythroid cell survival, proliferation and differentiation. Biochemical and structural analysis of the erythropoietin receptor (EpoR) is revealing the molecular mechanisms of EpoR function, leading the way to the development of small molecule Epo mimetics. This review focuses on the role EpoR dimerization plays in receptor function.