Development of in vivo tooth EPR for individual radiation dose estimation and screening.
Development of in vivo tooth EPR for individual radiation dose estimation and screening.
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DOI：
10.1097/hp.0b013e3181a6de5d
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发表时间：
2010-02
期刊：
影响因子：
2.2
通讯作者：
Swartz HM
中科院分区：
文献类型：
--
作者：
Williams BB;Dong R;Kmiec M;Burke G;Demidenko E;Gladstone D;Nicolalde RJ;Sucheta A;Lesniewski P;Swartz HM
体内 EPR 的发展使得原位进行牙齿剂量测量成为可能，极大地扩展了使用这种方法在辐射暴露后立即筛查的潜力。通过一系列实验建立了体内牙齿剂量测定提供吸收剂量估计值的能力，这些实验使用未受辐射的志愿者，将经过专门辐射的臼齿原位放置在其牙列间隙内以及已完成头颈癌放射治疗过程的患者的天然犬牙中。对接受放射治疗的患者进行的多次测量表明了预期的异质剂量分布。剂量响应曲线已使用两个群体生成，并且使用当前的方法和仪器，基于单次 4.5 分钟测量的预测标准误差对于插入的臼齿约为 1.5 Gy，对于形状更不规则的犬齿而言约为 2.0 至 2.5 Gy。独立测量的平均值可以将该误差显着降低至接近 1 Gy 的值。减少这些误差的开发正在进行中，重点是谐振器的几何优化、探测器定位技术和最佳数据平均方法。总之，EPR 剂量测定技术似乎有可能在涉及大量个体的暴露的回顾性剂量测定中发挥重要作用。
The development of in vivo EPR has made it feasible to perform tooth dosimetry measurements in situ, greatly expanding the potential for using this approach for immediate screening after radiation exposures. The ability of in vivo tooth dosimetry to provide estimates of absorbed dose has been established through a series of experiments using unirradiated volunteers with specifically irradiated molar teeth placed in situ within gaps in their dentition and in natural canine teeth of patients who have completed courses of radiation therapy for head and neck cancers. Multiple measurements in patients who have received radiation therapy demonstrate the expected heterogeneous dose distributions. Dose response curves have been generated using both populations and, using the current methodology and instrument, the standard error of prediction based on single 4.5 minute measurements is approximately 1.5 Gy for inserted molar teeth and between 2.0 and 2.5 Gy in the more irregularly shaped canine teeth. Averaging of independent measurements can reduce this error significantly to values near 1 Gy. Developments to reduce these errors are underway, focusing on geometric optimization of the resonators, detector positioning techniques, and optimal data averaging approaches. In summary, it seems plausible that the EPR dosimetry techniques will have an important role in retrospective dosimetry for exposures involving large numbers of individuals.