Increased circulating conjugated primary bile acids are associated with hyperandrogenism in women with polycystic ovary syndrome
Increased circulating conjugated primary bile acids are associated with hyperandrogenism in women with polycystic ovary syndrome
复制标题
循环中结合初级胆汁酸的增加与多囊卵巢综合征女性的高雄激素血症有关
DOI：
10.1016/j.jsbmb.2019.03.005
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发表时间：
2019-05-01
影响因子：
4.1
通讯作者：
Zhu, Dalong
中科院分区：
文献类型：
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作者：
Zhang, Bingjie;Shen, Shanmei;Zhu, Dalong
多囊卵巢综合征（PCOS）是一种常见的以高雄激素血症为核心病理生理特征的代谢紊乱性疾病。胆汁酸增加和胆汁酸池组成改变与几种代谢疾病的发病机制有关。因此，本研究旨在阐明PCOS患者循环胆汁酸的特异性改变，并探讨其与高雄激素血症的关系。我们招募了37名PCOS患者和35名年龄和BMI匹配的对照组。通过超高效液相色谱-串联质谱法（UPLC-MS/MS）评估血清胆汁酸和雄激素特征。与对照组相比，PCOS患者的甘氨酸和牛磺酸结合的初级胆汁酸显著升高（P = 0.001和P < 0.001）。此外，这些结合初级胆汁酸与PCOS组血清总睾酮和雄烯二酮浓度显著正相关。总之，循环结合初级胆汁酸增加与PCOS妇女高雄激素血症呈正相关。进一步的研究是必要的，以探讨其潜在的机制。
Polycystic ovary syndrome (PCOS) is a common metabolic disorder with hyperandrogenism as the core pathophysiologic feature. Increased bile acids and altered bile acid pool composition have been implicated in the pathogenesis of several metabolic diseases. Thus, this study aimed to clarify the specific alterations in circulating bile acids in patients with PCOS and investigate its associations with hyperandrogenism. We recruited 37 patients with PCOS and 35 age- and BMI-matched control subjects. Serum bile acids and androgen profiles were assessed by ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). Compared with control subjects, glycine- and taurine-conjugated primary bile acids were significantly elevated in patients with PCOS (P = 0.001 and P < 0.001). In addition, these conjugated primary bile acids were significantly and positively associated with serum concentrations of total testosterone and androstenedione in the PCOS group. In conclusion, increased circulating conjugated primary bile acids are positively associated with hyperandrogenism in women with PCOS. Further studies are warranted to explore the underlying mechanism.