Safower Yellow Improves Synaptic Plasticity in APP/PS1 Mice by Regulating Microglia Activation Phenotypes and BDNF/TrkB/ERK Signaling Pathway
Safower Yellow Improves Synaptic Plasticity in APP/PS1 Mice by Regulating Microglia Activation Phenotypes and BDNF/TrkB/ERK Signaling Pathway
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Safower Yellow 通过调节小胶质细胞激活表型和 BDNF/TrkB/ERK 信号通路改善 APP/PS1 小鼠的突触可塑性
作者：
Jie Pang;Jiawei Hou;Zhangjiuzhi Zhou;Mengqiao Ren;Yuyan Mo;Guang Yang;Zuwei Qu;Yanli Hu
Alzheimer’s disease (AD) is a common neurodegenerative disease that is always accompanied by synaptic loss in the brain..Safflower yellow (SY) is the extract of safflower, a traditional Chinese medicine, which has shown neuroprotective effects in.recent studies. However, the mechanism of SY in protecting synapses remains unclear. In this study, we are going to study.the mechanism of how SY treats AD in terms of synaptic plasticity. We found, via behavioral experiments, that SY treatment.could improve the abilities of learning and memory in APP/PS1 mice. In addition, using Golgi staining and HE staining,.we found that SY treatment could reduce the loss of dendritic spines in the pathological condition and could maintain the.normal physiological state of the cells in cortex and in hippocampus. In addition, the results of immunofluorescence staining.and western blotting showed that SY treatment could significantly increase the expression of synapse-related proteins..Moreover, after being treated with SY, the expression of iNOS (marker of M1 microglia) declined remarkably, and the level.of Arginase-1 (marker of M2 microglia) increased significantly. Finally, we found BDNF/TrkB/ERK signaling cascade was.activated. These results indicate that SY enhances synaptic plasticity in APP/PS1 mice by regulating microglia activation.phenotypes and BDNF/TrkB/ERK signaling pathway
